Table 1.
Demographic and biochemical indices of nutritional status and mineral metabolism of enrolled MHD patients (n=134)
| Group I | Group II | Group III | P for Trenda | |
|---|---|---|---|---|
| Urine = 0 ml/d (n=50) | Urine ≤200 ml/d (n=44) | Urine >200 ml/d (n=40) | ||
| Demographic characteristics | ||||
| Sex (% male) | 40.0 | 54.6 | 50.0 | 0.31 |
| Age (yr) | 62.5±10.8 | 61.1±12.4 | 60.3±12.5 | 0.50 |
| Dialysis vintage (yr) | 10.1 (5.4, 12.9) | 3.5 (1.7, 7.3) | 1.5 (0.7, 2.0) | <0.001 |
| Diabetes (%) | 6.0 | 18.2 | 17.5 | 0.10 |
| Systolic BP (mmHg) | 119.9±21.2 | 130.1±19.5 | 126.0±14.4 | 0.14 |
| Diastolic BP (mmHg) | 68.8±12.7 | 73.4±11.6 | 74.9±11.0 | 0.03 |
| Triacetate/polysulfone (n:n) | 10:40 | 9:35 | 9:31 | 0.78 |
| Kt/V-dialysis | 1.5±0.3 | 1.4±0.2 | 1.4±0.3 | 0.27 |
| GFR (ml/min per 1.73 m2) | 0 | 0.4 (0.2, 0.5) | 2.8 (1.8, 5.4) | <0.001 |
| Urinary output (ml/d) | 0 | 100 (50, 200) | 563 (343, 908) | <0.001 |
| Nutritional status | ||||
| BMI (kg/m2) | 20.7±3.1 | 21.7±2.9 | 21.4±3.0 | 0.24 |
| nPNA (g/kg per day) | 1.1±0.2 | 1.1±0.2 | 1.1±0.2 | 0.69 |
| Serum creatinine (mg/dl) | 10.6±1.9 | 11.0±2.1 | 8.4±2.6 | <0.001 |
| BUN (mg/dl) | 72.3±12.3 | 72.5±11.5 | 61.9±12.0 | <0.001 |
| Hemoglobin (g/dl) | 11.2±1.3 | 10.7±2.0 | 10.7±1.6 | 0.16 |
| Hematocrit (%) | 34.4±3.7 | 33.6±3.7 | 32.7±4.7 | 0.14 |
| Albumin (g/dl) | 3.9±0.2 | 3.9±0.2 | 3.9±0.3 | 0.43 |
| Mineral metabolism | ||||
| Phosphate (mg/dl) | 5.9±1.5 | 5.9±1.6 | 4.8±1.4 | 0.002 |
| Calcium (mg/dl) | 9.8±0.8 | 9.3±1.1 | 9.0±0.8 | <0.001 |
| iPTH (pg/ml) | 471.1±477.1 | 293.7±229.2 | 248.8±210.3 | 0.02 |
| FGF-23 (pg/ml) | 470.2±377.5 | 435.5±381.5 | 134.6±213.4 | <0.001 |
| α-Klotho (pg/ml) | 316.6±111.0 | 239.8±42.7 | 341.0±197.8 | 0.90 |
| 1,25(OH)2D3 (pg/ml) | 3.5±2.9 | 4.6±4.3 | 4.3±2.9 | 0.19 |
| Clinic medications | ||||
| Dosage of calcitriol (μg/w) | 1.1±2.2 | 0.8±1.3 | 1.0±1.6 | 0.50 |
| Dosage of CaCO3 (g/d) | 3.6±2.2 | 3.0±1.9 | 2.2±2.2 | 0.003 |
| Low calcium dialysis (%) | 30.0 | 15.9 | 7.5 | 0.01 |
Values indicate means ± SDs, medians (interquartile ranges), or proportions. MHD, maintenance hemodialysis; BMI, body mass index; nPNA, normalized protein nitrogen appearance; iPTH, intact parathyroid hormone; FGF-23, fibroblast growth factor-23.
a
Significance for trend was tested across all three groups. All patients were treated with the same agents of active vitamin D and phosphate binder. Low calcium dialysis was defined by the concentration of calcium in the dialysate, which was 2.5 mEq/L (1.25 mmol/L).