Table 3.
Post-transplant hospital events stratified by recovery status after AKI
| No AKI (n=233; 35%) | AKI with Recovery (n=142; 22%) | AKI with No Recovery (n=282; 43%) | P Valuea | |
|---|---|---|---|---|
| Intraoperative use of inotrope/vasopressors | 141 (61%) | 104 (76%)b | 213 (76%)b | 0.001 |
| Intraoperative central venous pressure (cmH2O)c | 14±5 | 15±6 | 15±6 | 0.13 |
| Intraoperative mean arterial pressure (mm)c | 89±16 | 85±15b | 87±16b | 0.01 |
| Inotrope/vasopressors use in ICU | 141 (61%) | 104 (74%)b | 211 (75%)b | 0.001 |
| PaO2/FiO2 at ICU admission | 298±121 | 247±128b | 274±137b | <0.001 |
| Extracorporeal membrane oxygenation | 1 (0.5%) | 3 (2%) | 8 (3%)b | 0.08 |
| Reintubation | 34 (15%) | 57 (40%)b | 83 (30%)b | <0.001 |
| Days on mechanical ventilation | 2±2 | 4±7b | 4±6b | <0.001 |
| Primary graft dysfunction (n=146) | 2/49 (4%) | 4/21 (19%)b | 11/76 (14%)b | 0.08 |
| Cardiac complication in ICU | 30 (13%) | 41 (29%)b | 92 (32%)b | <0.001 |
| Respiratory complication in ICU | 37 (16%) | 45 (32%)b | 92 (33%)b | <0.001 |
| Infectious complication in ICU | 15 (6%) | 40 (28%)b | 67 (24%)b | <0.001 |
| Renal complication in ICU | ||||
| AKIN-1 | 124 (88%) | 184 (66%)d | <0.001 | |
| AKIN-2 | 6 (4%) | 30 (10%)d | <0.001 | |
| AKIN-3 | 12 (8%) | 68 (24%)d | <0.001 | |
| Renal replacement therapy | 7 (5%) | 38 (13%)d | <0.001 | |
| Median length of stay (25th to 75th percentile; d) | 11 (9–17) | 17 (12–32) | 16 (12–28)b | <0.001 |
| Death at hospital discharge | 2 (1%) | 6 (4%) | 27 (10%)b | <0.001 |
Plus–minus values are mean ± SD. Cardiac complication is asystole/atrial arrhythmia/ventricular tachycardia or fibrillation/heart block/permanent pacer. Respiratory complication is acute respiratory distress syndrome/aspiration/tapped pleural effusion/pneumothorax/pulmonary embolus/pulmonary hemorrhage/hemothorax/chylothorax/respiratory failure. Infection complication is fungemia/bacteremia/line sepsis/septic shock/empyema/endocarditis/mediastinitis/wound infection/pneumonia/urinary tract infection. ICU, intensive care unit; PaO2, partial pressure of oxygen in arterial blood; FiO2, fraction of inspired oxygen; AKIN, AKI network.
P value for trend comparison across all three groups.
P<0.02 was considered significant (Bonferonni correction) for comparison between AKI with recovery or no recovery and no AKI.
Hemodynamics at time of anesthesia induction.
P<0.02 was considered significant (Bonferonni correction) for comparison between AKI with recovery and AKI with no recovery.