Table 1.

Effect of curcumin, hexahydrocurcumin, 5-fluorouracil and their combined treatment on aberrant crypt foci formation in rats exposed to dimethylhydrazine

Groups	Total ACF	Large ACF
Vehicle	1558.20 ± 17.37	262.20 ± 10.18
5-FU	1231.20 ± 25.62b	111.00 ± 7.88b
CUR	1284.20 ± 25.47b	178.00 ± 7.33b
HHC	1086.80 ± 53.47b	186.60 ± 21.51b
5-FU + CUR	880.20 ± 13.67bdf	122.00 ± 5.94b
5-FU + HHC	665.80 ± 16.64bdh	119.00 ± 17.92bh

Each value is represented by mean ± SE.

^bP < 0.01 vs vehicle group;

^dP < 0.01 vs 5-fluorouracil (5-FU) monotherapy;

^fP < 0.01 vs curcumin (CUR) monotherapy;

^hP < 0.01 vs hexahydrocurcumin (HHC) monotherapy. ACF: Aberrant crypt foci.