Table 3.
Genotype distributions of interleukin-1B-31, interleukin-1B-511 and interleukin-1RN gene polymorphisms among gastric cancer cases and controls from the Tibet, Hui and Han ethnicities n (%)
| Genotype |
Tibet |
Hui |
Han |
|||||||||
| Cases | Controls | OR (95%CI)1 | P value | Cases | Controls | OR (95%CI)1 | P value | Cases | Controls | OR (95%CI)1 | P value | |
| IL-1B-31 | ||||||||||||
| TT | 23 (14.84) | 47 (22.38) | 1 | 46 (29.11) | 59 (28.78) | 1 | 40 (20.30) | 65 (32.18) | 1 | |||
| CT | 81 (52.26) | 112 (53.33) | 1.47 (0.81-2.66) | 0.208 | 79 (50.00) | 105 (51.22 | 0.97 (0.58-1.62) | 0.896 | 102 (51.77) | 98 (48.52) | 1.69 (1.03-2.76) | 0.036 |
| CC | 51 (32.90) | 51 (24.29) | 2.10 (1.09-4.04) | 0.027 | 33 (20.89) | 41 (20.00) | 1.03 (0.55-1.95) | 0.919 | 55 (27.92) | 39 (19.31) | 2.29 (1.28-4.10) | 0.005 |
| IL-1B-511 | ||||||||||||
| CC | 34 (21.94) | 55 (26.19) | 1 | 33 (20.89) | 43 (20.98) | 1 | 31 (15.74) | 65 (32.17) | 1 | |||
| CT | 80 (51.61) | 93 (44.29) | 1.37 (0.80-2.35) | 0.210 | 88 (55.70) | 110 (53.66) | 1.04 (0.59-1.83) | 0.888 | 101 (51.27) | 99 (49.09) | 2.16 (1.28-3.65) | 0.004 |
| TT | 41 (26.45) | 62 (29.52) | 1.02 (0.56-1.86) | 0.945 | 37 (23.41) | 52 (25.37) | 0.96 (0.50-1.84) | 0.891 | 65 (32.99) | 38 (18.81) | 3.53 (1.49-8.33) | 0.004 |
| IL-1RN | ||||||||||||
| L/L | 129 (83.22) | 185 (88.10) | 1 | 94 (59.49) | 156 (76.10) | 1 | 166 (84.26) | 171 (84.66) | 1 | |||
| 2/L | 26 (16.78) | 25 (11.90) | 1.50 (0.80-2.79) | 0.206 | 64 (40.50) | 49 (23.90) | 2.11 (1.31-3.40) | 0.002 | 31 (15.28) | 31 (14.44) | 1.03 (0.59-1.79) | 0.924 |
1
Adjusted for age, sex, smoking status and Helicobacter pylori infection. IL: Interleukin; OR: Odds ratio.