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Ala-6774.40, Ala-6814. 44, and Ala-6854.48 are critical for mGlu2 to form a receptor heteromer with 5-HT2A. A, ribbon backbone representation of the transmembrane helices of the 5-HT2A·mGlu2 heteromer model. Residues Ala-6774.40, Ala-6814.44, and Ala-6854.48 are shown as spheres. B, ribbon backbone representation of the transmembrane helices of the 5-HT2A·mGlu2ΔTM4N heteromer model. Residues Ser-6774.40, Phe-6814.44, and Gly-6854.48 are shown as spheres.
