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. 2012 Nov 6;287(53):44694–44702. doi: 10.1074/jbc.M111.309450

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — BTT-3033, but not BTT-3034, blocks CHO-α2E336A cell binding to collagen under flow. The selectivity of BTT-3033 for the nonactivated α2β1 integrin was confirmed in assays testing CHO-α2E336A cell binding under flow conditions (90 dynes/cm²) using a Cellix microfluidic platform. A, BTT-3033 (at EC₅₀ concentration) inhibited CHO-α2E336A cell adhesion to collagen I. The data expressed are the mean ± S.E. of 13 independent experiments. Significant difference between Control and BTT-3033 is indicated by an asterisk (Wilcoxon Rank-Sum test, *, p = 0.028). B, BTT-3034 (at EC₅₀ concentration) had no inhibitory effect on CHO-α2E336A cell adhesion to collagen I at a high shear rate. The data expressed are the mean ± S.E. of nine independent experiments.