FIGURE 2.

Comparison of DAD2 and GID1 structures. Diagrams of the protein structures of DAD2 (left) and GID1 (right) looking down onto the lid (A,B) and from the side (C,D). Both proteins have the core α/β hydrolase fold of alternating α helices and β sheets (gray). The proteins have “lids” made up of four α helices (orange for DAD2, blue for GID1) that extend over an internal cavity (shaded, red DAD2, pale blue GID1). Reprinted from Hamiaux et al. (2012), Copyright (2012) with permission from Elsevier.