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Hypothetical model linking Treg cell suppressive function to FOXP3 expression level. In this model, high expression of FOXP3 in T cells endows them with enhanced suppressive capacity and a characteristic phenotype. Absence of FOXP3 expression is associated with no suppressive capacity, but reduced FOXP3 expression may result in an intermediate phenotype without suppressive function, and possibly a tendency for enhanced functional plasticity.
