Figure 5.
PRSS3 silencing inhibits anchorage independent growth of prostate cancer cells. PC3-M cells transduced with shRNA virus targeting PRSS3 (KD) or with a nontarget control virus (NT) were plated in soft agar and grown for 2 weeks. Cells in which PRSS3 expression was suppressed showed significantly fewer colonies per well. Photographs of representative fields are shown above graphical results. ***, p<0.0001; bars, SEM; n=4 biological replicates.