Table 1.
Bioactivities (Ki in µM; pKi) measured in same assay type (‘Increase in X intracellular accumulation’): different substrates, same cell line.
| Cell line=LLC-PK1 | Ki (µM), Calcein | pKi | Ki (µM), [3H]-Vinblastine | pKi |
|---|---|---|---|---|
| Bromocriptine | 2.8 | 5.6 | 4.0 | 5.4 |
| Clotrimazole | 44.0 | 4.4 | 29.9 | 4.5 |
| Cyclosporin A | 4.7 | 5.3 | 1.3 | 4.9 |
| Dihydro-ergocristine | 511.0 | 3.3 | 16 | 4.8 |
| Dihydro-ergocryptine | 360.5 | 3.4 | 19.8 | 4.7 |
| Dihydro-ergotamine | >1000 | <3.0 | 119.9 | 3.9 |
| Ergocornine | 105.2 | 4.0 | 24.5 | 4.6 |
| Ergocristine | 42.8 | 4.4 | 13.3 | 4.9 |
| Ergocryptine | 12.2 | 4.9 | 6.4 | 5.2 |
| Ergometrine | 115.5 | 3.9 | >100 | 4.0 |
| Ergotamine | 98.9 | 4.0 | 14.3 | 4.8 |
| Erythromycin | >1000 | <3.0 | 37.8 | 4.4 |
| Fluconazole | >1000 | <3.0 | >400 | 3.4 |
| Ketoconazole | 24.9 | 4.6 | 5.3 | 5.3 |
| Miconazole | 55.5 | 4.3 | 26.4 | 4.6 |
| Reserpine | 12.2 | 4.9 | 1.0 | 6.0 |
| Troleandomycin | 483.3 | 3.3 | 87.6 | 4.1 |