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Bioactivities (IC50 in µM; pIC50) measured in same assay type (‘Increase in X intracellular accumulation’): different substrate, different cell lines.
| IC50 (µM), Calcein/L-MDR1 | pIC50 | IC50(µM), DNR/NIH-3T3-G185 | pIC50 | |
|---|---|---|---|---|
| Cyclosporin A | 0.8 | 6.1 | 1.4 | 5.9 |
| Itraconazole | 2.1 | 5.7 | 1.7 | 5.8 |
| Ketoconazole | 4.8 | 5.3 | 5.6 | 5.3 |
| Nicardipine | 2.3 | 5.6 | 3.2 | 5.5 |
| Quinidine | 5.6 | 5.3 | 18.8 | 4.7 |
| Terfenadine | 1.4 | 5.9 | 1.8 | 5.7 |
| Verapamil | 6.3 | 5.2 | 4.2 | 5.4 |
| Vinblastine | >50 | 4.3 | 17.7 | 4.8 |
