Table 2.
Chromosome locations of some of the genes involved in lipid metabolism that are associated with schizophrenia.
| Locations of mutations in schizophrenic families | Proteins involved in the metabolism of phospholipid and fatty acids | Chromosome locations of their genes |
|---|---|---|
| 2p25-p21 (Moises et al., 1995) | Apolipoprotein B | 2p24 |
| 11q22-q23 (Riley and Williamson, 2000) | Apolipoprotein A-IV | 11q23 |
| 1q22-q23 (Shaw et al., 1998) | Apolipoprotein A-II | 1q21–1q23 |
| 16q22 (Shaw et al., 1998) | Lecithin: cholesterol acyl transferase | 16q22.1 |
| 8p21-p23 (Pulver et al., 1995; Straub et al., 1997; Blouin et al., 1998; Brzustowicz et al., 1999; Gurling et al., 1999; Mors and Ewald, 1999) | Lipoprotein lipase | 8p21–22 |
| 7q11 (Blouin et al., 1998) | Fatty acid transport protein | 7q11.2 |
| 9q34.3 (Riley and Williamson, 2000) | Carnitine acetyl transferase | 9q34.1 |
| 11q14-24 (Gurling et al., 1999) | Carnitine palmitoyl transferase-I | 11q13.1–13.5 |
| 2q21 (Barnes et al., 1999) | Acyl coenzyme A binding protein | 2q12–q21 |
| 9p23-p21 (Moises et al., 1995) | Phospholipase A2 activating protein | 9p21 |
| 9q32 (Barnes et al., 1999) | Cyclooxygenase-1 | 9q32–33.3 |
| 20p12 (Moises et al., 1995) | Phospholipase C, Beta 4 | 20p12 |
| 20q13 (Barnes et al., 1999) | Phospholipase C, Gamma 1 | 20q12–q13.1 |
| 22q11-q13 (Pulver et al., 1995, 22q (Hovatta et al., 1998) | Phospholipase A2, Group VI | 22q13.1 |
Chromosome locations of some of the genes whose proteins are involved in various stages of the fatty acid transport, phospholipid side chain replacements, and inter-conversion of different lipoproteins are shown.