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. 2012 Nov 13;8:622. doi: 10.1038/msb.2012.53

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Copyright © 2012, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Simulated Hog1 phosphorylation and volume dynamics for 0.4 M NaCl osmotic shock for cases where several feedback mechanisms are selectively shut off. W/o denotes ‘without’. FB denotes feedback. Blue line: wild type. Brown line: without Hog1-mediated feedback on both upstream signalling branches. Orange line: without Hog1-mediated feedback on the Sho1 branch. Light orange line: without Hog1-mediated feedback on the Sln1 branch. Dark grey line: without Fps1 closure. Grey line: without Hog1-mediated Fps1 closure. Light grey line: without turgor-mediated Fps1 closure. Green line: without transcription. Red line: without Hog1-mediated glycerol production.