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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: ChemMedChem. 2012 May 23;7(7):1286–1294. doi: 10.1002/cmdc.201200104

Figure 1.

Figure 1

(A) Previously synthesized Arp2/3 complex inhibitors 1 and 12. Compound 1 was used as a parent scaffold for substitutions indicated in Scheme 1. (B) Crystal structure of 1 bound to Bos taurus Arp2/3 complex. 1 is shown as spheres and binds at the interface of the Arp3 (orange) and Arp2 (red) subunits. The five other subunits in the complex are labeled ARPC1-5. (C). Comparison of 1 (grey carbon atoms) with 12 (turquoise carbon atoms) showing a close up of the binding pocket at the interface of Arp2 and Arp3. Coordinates for 12 for this figure were generated by overlaying Arp2 and Arp3 from 3DXK.pdb onto the structure of 1 and applying the transformation to 12.