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. Author manuscript; available in PMC: 2012 Dec 28.
Published in final edited form as: Nat Med. 2012 May;18(5):820–823. doi: 10.1038/nm.2724

Figure 3. LepR-bNOS1 neurons contribute modestly to endocrine functions.

Figure 3

Serum T4 (a) and corticosterone (b) concentrations from 7–8 week old male control (Ctrl), LeprNOS1KO and LeprKO mice. All measurements, n ≥ 5. Graphed data represent average values ± SEM. (c) Analysis of time to first estrus for female Ctrl and LeprNOS1KO mice; percent exhibiting vaginal estrus is plotted by age. All measurements, n ≥ 9. (d) Analysis of reproductive competence in female Ctrl, LeprNOS1KO and LeprKO mice. Experimental animals were mated with C57Bl/6 males and the delivery of pups was monitored daily. Percent delivering pups by days post-mating is plotted. All measurements, n ≥ 8. ANOVA: *, p < 0.05 vs Ctrl; **, p < 0.01 vs Ctrl; ***, p < 0.001 vs Ctrl; #, p < 0.05; all other comparisons, p = NS.