Table 2.
Comparison of agreement between clinical diagnoses assigned at the Mulago National Referral Hospital in Uganda for non- Hodgkin lymphoma (including Burkitt’s lymphoma), other cancer, and noncancerous chronic conditions, and the pathology laboratories in Uganda and The Netherlands, for the 118 children with complete diagnostic informationa
| Clinical diagnosis from Uganda | ||||
|---|---|---|---|---|
|
|
||||
| NHL, n (%) | Other cancer, n (%) | NCCC, n (%) | Total, n (%) | |
| Pathological diagnosis from Uganda | ||||
| NHL | 58 (94) | 1 (2) | 3 (5) | 62 (100) |
| Other cancer | 1 (8) | 9 (69) | 3 (23) | 13 (100) |
| NCCC | 1 (2) | 2 (5) | 40 (93) | 43 (100) |
| Total | 60 (51) | 12 (10) | 46 (39) | 118 (100) |
| Kappa test statistic (95% CI) | 0.84b (0.75, 0.92) | |||
| P value of the kappa statistics | <0.001 | |||
| Percentage of agreement (95% CI) | 91% (84%, 95%) | |||
| Pathological diagnosis from The Netherlands | ||||
| NHL | 46 (53) | 8 (9) | 33 (38) | 87 (100) |
| Other cancer | 1 (50) | 0 (0) | 1 (50) | 2 (100) |
| NCCC | 13 (45) | 4 (14) | 12 (41) | 29 (100) |
| Total | 60 (51) | 12 (10) | 46 (39) | 118 (100) |
| Kappa test statistic (95% CI) | 0.04 (−0.10, 0.17) | |||
| P value of the kappa statistics | 0.612 | |||
| Percentage of agreement (95% CI) | 49% (40%, 59%) | |||
Notes:
Complete diagnostic information: clinical diagnosis, pathological diagnosis assigned in Uganda and pathological diagnosis assigned in The Netherlands;
we also performed a kappa test result including 268 children with both preliminary clinical diagnosis and pathological diagnosis from Uganda, which yielded a kappa statistic of 0.74 (95% CI 0.66–0.81; P < 0.0001), and a percentage agreement of 84% (95% CI 79–88).
Abbreviations: CI, confidence interval; NHL, non-Hodgkin lymphoma; NCCC, noncancerous chronic condition; n, number of children.