Table 3.
Comparison of agreement between clinical diagnosis at the Mulago National Referral Hospital in Uganda for Burkitt’s lymphoma, other non-Hodgkin lymphoma (excluding Burkitt’s lymphoma), other cancer, and noncancerous chronic conditions, and pathology laboratories in Uganda and in The Netherlands, for the 118 children with complete diagnostic informationa
Clinical diagnosis from Uganda | Total, n (%) | ||||
---|---|---|---|---|---|
|
|||||
BLb, n (%) | Other NHL, n (%) | Other cancer, n (%) | NCCC, n (%) | ||
Pathological diagnosis from Uganda | |||||
BL | 21 (62) | 10 (29) | 0 (0) | 3 (9) | 34 (100) |
Other NHL | 16 (57) | 11 (39) | 1 (4) | 0 (09) | 28 (100) |
Other cancer | 0 (0) | 1 (8) | 9 (69) | 3 (239) | 13 (100) |
NCCC | 1 (2) | 0 (0) | 2 (5) | 40 (939) | 43 (100) |
Total | 38 (32) | 22 (19) | 12 (10) | 46 (399) | 118 (100) |
Kappa test statistic (95% CI) | 0.56 (0.44–0.67) | ||||
P value of the kappa statistics | <0.0001 | ||||
Percentage of agreement (95% CI) | 69% (59%, 77%) | ||||
Pathological diagnosis from The Netherlands | |||||
BL | 19 (45) | 10 (24) | 0 (0) | 13 (31) | 42 (100) |
Other NHL | 10 (22) | 7 (16) | 8 (18) | 20 (44) | 45 (100) |
Other cancer | 1 (50) | 0 (0) | 0 (0) | 1 (50) | 2 (100) |
NCCC | 8 (28) | 5 (17) | 4 (14) | 12 (41) | 29 (100) |
Total | 38 (32) | 22 (19) | 12 (10) | 46 (39) | 118 (100) |
Kappa test statistic (95% CI) | 0.05 (−0.06, 0.16) | ||||
P value of kappa statistics | 0.326 | ||||
Percentage of agreement (95% CI) | 32% (24%, 41%) |
Notes:
Complete diagnostic information: clinical diagnosis, pathological diagnosis assigned in Uganda, and pathological diagnosis assigned in The Netherlands;
combination of variable clinical diagnosis of NHL from Uganda used in Table 2 and “assessment of facial tumor” (“yes” if patient had facial tumor, and “no” otherwise). A patient here is classified as BL if she or he had both a clinical diagnosis of NHL and a facial tumor.
Abbreviations: BL, Burkitt’s lymphoma; NHL, non-Hodgkin lymphoma; NCCC, noncancerous chronic condition; n, number of children.