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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Neuropharmacology. 2012 Jun;62(8):2480–2488. doi: 10.1016/j.neuropharm.2012.02.022

Fig. 3.

Fig. 3

Altered γ-aminobutyric acid (GABA) and glutamate levels during ethanol withdrawal and acamprosate treatment effect in ENT1 null and wild-type mice. (A) GABA is significantly reduced in the medial prefrontal cortex (mPFC) of wild-type and ENT1 null mice during ethanol withdrawal. Acamprosate treatment (200 mg/kg/injection twice a day) reversed this effect in ENT1 null mice. (B) Glutamate + glutamine (Glx) levels were significantly increased during ethanol withdrawal in the nucleus accumbens (NAc) of wild-type mice while basal Glx levels in ENT1 null mice were significantly increased compared to wild-type mice. Acamprosate treatment reduced Glx in both wild-type and ENT1 null mice compared to withdrawal conditions. All data are presented as mean percent of wild-type basal level ± standard error of the mean (SEM). * p < 0.05 by two-way repeated measures ANOVA followed by Tukey post-hoc test for individual comparisons.