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. 2012 Feb 15;32(7):2410–2421. doi: 10.1523/JNEUROSCI.5205-11.2012

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Copyright © 2012 the authors 0270-6474/12/322410-12$15.00/0

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Figure 3. — The BDNF Val66Met polymorphism impairs STDP in the IL-mPFC pyramidal neurons. A, Examples of EPSP recordings before and at 20 min after the pairing protocol. B, An example of STDP in the layer II/III pyramidal neuron from wild-type mouse. C, An example of STDP in the layer II/III pyramidal neuron from BDNF^Met/Met mouse. D, STDP in the layer II/III pyramidal neurons of BDNF^Met/Met (n = 8) and wild-type littermates (n = 8). STDP was absent in BDNF^Met/Met mice (F_(1,14) = 8.2, p < 0.01). E, STDP in the layer V pyramidal neurons of BDNF^Met/Met (n = 9) and wild-type littermates (n = 9). STDP was absent in BDNF^Met/Met mice (F_(1,16) = 6.6, p < 0.05).

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