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. 2012 Feb 15;32(7):2410–2421. doi: 10.1523/JNEUROSCI.5205-11.2012

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Copyright © 2012 the authors 0270-6474/12/322410-12$15.00/0

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Figure 5. — The BDNF Val66Met polymorphism suppresses GABAergic transmission in the IL-mPFC layer II/III and layer V pyramidal neurons. A, Examples of mIPSCs in the layer II/III pyramidal neurons of BDNF^Met/Met and wild-type littermates. B, C, Average mIPSC frequency (B) and amplitude (C) in the layer II/III pyramidal neurons of BDNF^Met/Met (n = 6) and wild-type mice (n = 6). The mIPSC frequency (p < 0.01) but not the amplitude (p > 0.05) was significantly lower in BDNF^Met/Met mice. D, E, Average mIPSC frequency (D) and amplitude (E) in the layer V pyramidal neurons of BDNF^Met/Met (n = 10) and wild-type mice (n = 8). Both the mIPSC frequency and amplitude were significantly lower in BDNF^Met/Met mice (p < 0.05). Asterisks denote statistical significance.