Figure 6.
BDNF reverses STDP deficit in the IL-mPFC pyramidal neurons of BDNFMet/Met mice. A, STDP in the layer II/III pyramidal neurons from BDNF-treated (n = 7) and untreated (n = 9) wild-type brain slices. BDNF treatment did not affect STDP in wild-type mice (p > 0.05). B, STDP in the layer II/III pyramidal neurons from BDNF-treated (n = 9) and untreated (n = 10) BDNFMet/Met brain slices. BDNF-treated BDNFMet/Met slices showed significant STDP compared with the untreated BDNFMet/Met slices (F(1,17) = 4.7, p < 0.05). C, STDP in the layer V pyramidal neurons from BDNF-treated (n = 9) and untreated (n = 10) wild-type brain slices. BDNF treatment did not affect STDP in wild-type mice (p > 0.05). D, STDP in the layer V pyramidal neurons from BDNF-treated (n = 9) and untreated (n = 10) BDNFMet/Met brain slices. BDNF-treated BDNFMet/Met slices showed significant STDP compared with the untreated BDNFMet/Met slices (F(1,17) = 8.9, p < 0.01).