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. 2012 Feb 15;32(7):2410–2421. doi: 10.1523/JNEUROSCI.5205-11.2012

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Copyright © 2012 the authors 0270-6474/12/322410-12$15.00/0

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Figure 7. — BDNF enhances NMDA receptor transmission in the IL-mPFC pyramidal neurons of both wild-type and BDNF^Met/Met mice. A, NMDA receptor transmission in the layer II/III pyramidal neurons from BDNF-treated (n = 7) and untreated (n = 9) wild-type brain slices. BDNF-treated wild-type slices showed significantly higher NMDA receptor transmission compared with the untreated wild-type slices at stimulation strength 100, 150, and 200 μA (p < 0.05). B, NMDA receptor transmission in the layer II/III pyramidal neurons from BDNF-treated (n = 9) and untreated (n = 10) BDNF^Met/Met brain slices. BDNF-treated BDNF^Met/Met slices showed significantly higher NMDA receptor transmission compared with the untreated BDNF^Met/Met slices (F_(1,17) = 21.3, p < 0.001). C, NMDA receptor transmission in the layer V pyramidal neurons from BDNF-treated (n = 7) and untreated (n = 9) wild-type brain slices. BDNF-treated wild-type slices showed significantly higher NMDA receptor transmission compared with the untreated wild-type slices above the stimulation strength of 250 μA (p < 0.01). D, NMDA receptor transmission in the layer V pyramidal neurons from BDNF-treated (n = 8) and untreated (n = 9) BDNF^Met/Met brain slices. BDNF-treated BDNF^Met/Met slices showed significantly higher NMDA receptor transmission compared with the untreated BDNF^Met/Met slices (F_(1,15) = 21, p < 0.001). Asterisks denote statistical significance.