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. 2012 Feb 15;32(7):2410–2421. doi: 10.1523/JNEUROSCI.5205-11.2012

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Copyright © 2012 the authors 0270-6474/12/322410-12$15.00/0

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Figure 9. — BDNF enhanced non-NMDA receptor transmission in the IL-mPFC pyramidal neurons of wild-type mice but not BDNF^Met/Met mice. A, Average non-NMDA EPSC amplitudes in the layer II/III pyramidal neurons from BDNF-treated (n = 6) and untreated wild-type brain slices (n = 10). BDNF treatment significantly enhanced non-NMDA receptor transmission in the wild-type neurons (F_(1,14) = 14.7, p < 0.01). B, Average non-NMDA EPSC amplitudes in the layer II/III pyramidal neurons from BDNF-treated (n = 9) and untreated BDNF^Met/Met brain slices (n = 7). BDNF treatment failed to enhance non-NMDA receptor transmission in the BDNF^Met/Met neurons (p > 0.05). C, Average non-NMDA EPSC amplitudes in the layer V pyramidal neurons from BDNF-treated (n = 7) and untreated wild-type brain slices (n = 5). BDNF treatment significantly enhanced non-NMDA receptor transmission in the wild-type neurons at stimulation strength >250 μA (F_(1,10) = 5.9, p < 0.05). D, Average non-NMDA EPSC amplitudes in the layer V pyramidal neurons from BDNF-treated (n = 6) and untreated BDNF^Met/Met brain slices (n = 6). BDNF treatment failed to enhance non-NMDA receptor transmission in the BDNF^Met/Met neurons (p > 0.05).

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