Table 3.
Adjusted health care costs during 12-month period following 5-ASA initiation, by 5-ASA adherence status
| Cost Outcome |
5-ASA Adherence Status |
||||
|---|---|---|---|---|---|
|
Adherent |
Not Adherent |
||||
| Mean Predicted Costa | 95% Confidence Interval | Mean Predicted Costa | 95% Confidence Interval | P Value | |
| Cost of inpatient admissions |
$14,541.65 |
[$14,313.80, $14,769.49] |
$28,726.65 |
[$28,443.11, $29,010.19] |
<0.0001 |
| Cost of ER visits |
$495.33 |
[$477.91, $512.76] |
$635.95 |
[$621.95, $649.94] |
<0.0001 |
| Cost of outpatient office visits |
$1,081.83 |
[$1,046.79, $1,116.87] |
$1,145.67 |
[$1,121.99, $1,169.35] |
0.0031 |
| Cost of other outpatient/ ancillary visits |
$3,702.39 |
[$3,602.08, $3,802.70] |
$4,923.29 |
[$4,837.67, $5,008.91] |
<0.0001 |
| Cost of pharmacy prescriptions |
$5,309.84 |
[$5,180.82, $5,438.86] |
$3,189.88 |
[$3,142.40, $3,237.35] |
<0.0001 |
| Cost of UC-related pharmacy prescriptions |
$3,568.57 |
[$3,519.87, $3,617.27] |
$1,718.20 |
[$1,702.68, $1,733.73] |
<0.0001 |
| Cost of non–UC-related pharmacy prescriptions |
$1,845.51 |
[$1,746.93, $1,944.09] |
$1,541.60 |
[$1,487.04, $1,596.17] |
<0.0001 |
| Cost of non-pharmacy visits |
$8,101.24 |
[$7,848.17, $8,354.30] |
$14,226.32 |
[$13,936.79, $14,515.85] |
<0.0001 |
| Cost of total visits | $13,464.89 | [$13,094.43, $13,835.35] | $17,339.36 | [$17,033.28, $17,645.45] | <0.0001 |
5-ASA = 5-aminosalicylate; ER = emergency department; UC = ulcerative colitis.
aPredicted costs are based on generalized linear models and control for age, gender, geographic region, health plan type, payer type, and Charlson Comorbidity Index scores. Separate models were run for each cost sector; therefore, the mean predicted cost for each sector does not sum up to the total predicted cost.