Table 5.
Estimated parameters of the conditional LCAs in the OHTS and EGPS data
|
OHTS | |||||||
|---|---|---|---|---|---|---|---|
|
Variables |
Parameters for IOP change and the effects of covariates on class membership |
Effects on POAG |
|||||
| Class 1 | Class2 (Ref.) | Class 3 | Class 4 | Class 5 | Class 6 | ||
|
Class Size IOP Change |
14.2% |
27.1% |
21.1% |
9.1% |
17.6% |
10.9% |
|
| I |
17.58(0.20)# |
19.83(0.21)# |
22.30(0.21)# |
22.82(0.79)# |
24.74(0.22)# |
27.70(0.28)# |
- |
| L |
−0.57(0.08)# |
−0.53(0.06)# |
−0.47(0.09)# |
−0.95(0.30)# |
−0.20(0.09)* |
0.16(0.17) |
- |
| Q |
0.06(0.01)# |
0.05(0.01)# |
0.05(0.01)# |
0.07(0.04) |
0.02(0.02) |
−0.05(0.03) |
- |
| V |
4.36(0.27)# |
4.30(0.32)# |
4.80(0.25)# |
16.07(1.46)# |
4.66(0.31)# |
12.15(1.15)# |
- |
|
Covariates |
|
|
|
|
|
|
|
| Intercept |
−2.64(0.63)# |
|
2.08(0.47)# |
−0.06(0.47) |
2.35(0.54)# |
1.04(0.61) |
- |
| TRT |
1.60(0.66)* |
- |
−3.25(0.35)# |
−2.19(0.63)# |
−5.98(0.56)# |
−6.46(0.70)# |
0.16(0.29) |
| MALE |
0.25(0.23) |
- |
−0.99(0.24)# |
0.24(0.27) |
−0.68(0.28)* |
−0.22(0.30) |
0.23(0.19) |
| RACEB |
−0.10(0.27) |
- |
−0.37(0.30) |
0.75(0.31)* |
−0.91(0.34)* |
0.05(0.37) |
−0.05(0.24) |
| AGE |
0.06(0.12) |
- |
−0.01(0.12) |
0.08(0.16) |
−0.05(0.14) |
0.13(0.15) |
0.18(0.09) * |
| IOP0 |
−0.79(0.18)# |
- |
0.21(0.22) |
1.03(0.36)* |
0.89(0.18)# |
1.73(0.22)# |
−0.10(0.11) |
| CCT |
−0.35(0.12)* |
- |
0.18(0.11) |
−0.08(0.17) |
0.14(0.13) |
0.09(0.16) |
−0.64(0.13)# |
| PSD |
0.13(0.11) |
- |
0.04(0.11) |
0.08(0.13) |
0.17(0.13) |
0.12(0.15) |
0.23(0.10)* |
| VCD |
0.06(0.11) |
- |
−0.08(0.12) |
−0.15(0.17) |
−0.10(0.13) |
−0.09(0.15) |
0.60(0.10)# |
| BB |
−0.60(0.48) |
- |
−0.37(0.61) |
- ** |
−0.30(0.62) |
−1.21(0.77) |
0.19(0.57) |
| CHB |
−0.19(0.37) |
- |
−0.32(0.42) |
0.47(0.45) |
−0.42(0.44) |
−0.50(0.49) |
0.09(0.31) |
| DM |
−0.23(0.35) |
- |
0.22(0.32) |
−0.71(0.45) |
0.23(0.36) |
0.64(0.40) |
−1.67(0.53)* |
| HEART |
0.70(0.44) |
- |
0.10(0.49) |
0.43(0.56) |
−0.09(0.56) |
−0.48(0.73) |
0.71(0.29)* |
| HBP |
0.47(0.24)* |
- |
0.40(0.27) |
0.06(0.34) |
0.41(0.30) |
0.66(0.33)* |
0.08(0.22) |
|
EGPS | |||||||
|
Variables |
Parameters for IOP change and the effects of covariates on class membership |
Effects on POAG |
|
||||
| |
Class1 (Ref.) |
Class 2 |
Class 3 |
Class 4 |
Class 5 |
|
|
|
Class Size IOP Change |
26.3% |
20.1% |
29.3% |
12.9% |
11.4% |
|
|
| I |
18.66(0.25) # |
18.24(0.18)# |
21.24(0.20)# |
21.85(0.47)# |
24.33(0.34)# |
- |
|
| L |
−0.34(0.14)* |
−1.29(0.18)# |
−0.25(0.11)* |
−1.76(0.28)# |
0.06(0.26) |
- |
|
| Q |
0.05(0.03) |
0.11(0.04)* |
0.02(0.03) |
0.02(0.07) |
−0.08(0.07) |
- |
|
| V |
3.79(0.23)# |
3.75(0.25)# |
4.59(0.24)# |
7.12(0.85)# |
12.17(1.32)# |
- |
|
|
Covariates |
|
|
|
|
|
|
|
| Intercept |
- |
−0.84(0.33)* |
0.30(0.28) |
−0.85(0.58) |
−0.71(0.34)* |
- |
|
| TRT |
- |
0.36(0.27) |
−0.65(0.23)* |
−0.58(0.37) |
−1.79(0.37)# |
−0.01(0.21) |
|
| MALE |
- |
−0.35(0.29) |
0.14(0.23) |
0.18(0.40) |
0.38(0.33) |
−0.24(0.22) |
|
| Black |
- |
- |
- |
- |
- |
- |
|
| AGE |
- |
−0.09(0.16) |
0.01(0.13) |
0.40(0.23) |
0.45(0.20)* |
0.16(0.10) |
|
| IOP0 |
- |
−0.61(0.24)* |
0.82(0.17)# |
1.24(0.24)# |
1.79(0.23)# |
0.11(0.13) |
|
| CCT |
- |
−0.33(0.13)* |
−0.14(0.12) |
−0.43(0.15)* |
0.09(0.15) |
−0.36(0.12)* |
|
| PSD |
- |
0.27(0.16) |
−0.23(0.14) |
−0.18(0.24) |
−0.41(0.23) |
0.18(0.09)* |
|
| VCD |
- |
−0.13(0.17) |
−0.03(0.13) |
0.72(0.26)* |
0.17(0.16) |
0.46(0.12)# |
|
| BB |
- |
−0.17(0.50) |
−0.82(0.52) |
- ** |
−0.58(0.69) |
−0.07(0.41) |
|
| CHB |
- |
−0.10(0.56) |
−0.97(0.52) |
0.89(1.03) |
−1.22(0.79) |
−0.28(0.47) |
|
| DM |
- |
−0.46(0.52) |
0.12(0.45) |
−1.32(1.27) |
0.82(0.81) |
−0.18(0.54) |
|
| HEART |
- |
0.78(0.41) |
0.11(0.44) |
−0.83(0.77) |
−0.79(0.61) |
0.74(0.32)* |
|
| HBP | - | 0.02(0.36) | 0.53(0.30) | −1.27(0.90) | 0.11(0.54) | 0.24(0.26) | |
*: p < 0.05; #: p < 0.001; **: Not estimable due to zero count of beta blocker use in the given class.