Table 3. Odds ratios (OR) estimates, with 95% confidence intervals (CI), for “low-count” CLL-like monoclonal B-cell lymphocytosis (60 out of 72 cases) by previous associated factors.
| ControlsN = 380 | MBL casesN = 60 | OR1 & 95% CI | |
| Age | |||
| <50 | 92 (24%) | 6 (10%) | Ref |
| 50–59 | 99 (26%) | 5 (8%) | 0.78 (0.23 to 2.66) |
| 60–69 | 78 (21%) | 16 (27%) | 3.19 (1.19 to 8.57) |
| 70–79 | 85 (22%) | 22 (37%) | 4.06 (1.56 to 10.52) |
| 80 or more | 26 (7%) | 11 (18%) | 6.56 (2.21 to 19.45) |
| mean (SD) | 60 (13) | 69 (12) | |
| P-trend<0.0001 | |||
| range | 40 to 97 | 43 to 93 | |
| Self-reported infectious diseases among | |||
| Children2 | 32 (8%) | 8 (13%) | 2.33 (0.95 to 5.69); P = 0.06 |
| Self-reported respiratory diseases among | |||
| Sibling3 | 7 (2%) | 4 (7%) | 4.32 (1.13 to 16.56); P = 0.03 |
| Self-reported vaccination against | |||
| Pneumococcus4 | 78 (41%) | 14 (29%) | 0.48 (0.24 to 0.99); P = 0.05 |
| Influenza | 153 (40%) | 26 (43%) | 0.58 (0.31 to 1.07); P = 0.08 |
| Self-reported respiratory tract infections | |||
| Pneumonia | 8 (2%) | 6 (10%) | 4.18 (1.31 to 13.27); P = 0.02 |
| Influenza | 1 (<1%) | 1 (2%) | 7.49 (0.35 to 162.48); P = 0.2 |
| Meningitis | 3 (<1%) | 1 (2%) | 9.79 (0.80 to 119.99); P = 0.07 |
| Number of children | |||
| None | 57 (15%) | 14 (23%) | 3.24 (0.96 to 10.85) |
| 1 | 67 (18%) | 4 (7%) | Ref |
| 2 | 141 (37%) | 11 (18%) | 1.07 (0.32 to 3.61) |
| 3 | 66 (18%) | 11 (18%) | 2.07 (0.59 to 7.32) |
| 4 or more | 46 (12%) | 20 (33%) | 4.23 (1.24 to 14.43) |
| P-trend (in parous)<0.0001 | |||
| Diabetes treatment | 44 (12%) | 3 (5%) | 0.27 (0.08 to 0.91); P = 0.04 |
| Ever had family history of haematological cancer | |||
| Ever (any family members)5 | 24 (6%) | 8 (13%) | 2.18 (0.88 to 5.40); P = 0.09 |
| 1st degree relatives5 | 22 (6%) | 8 (13%) | 2.36 (0.94 to 5.94); P = 0.07 |
| Father | 4 (1%) | 4 (7%) | 16.30 (3.30 to 80.58); P = 0.001 |
| Ever had family history of solid cancer | |||
| 1st degree relatives5 | 164 (43%) | 34 (57%) | 1.72 (0.97 to 3.08); P = 0.07 |
| Sibling 4 | 60 (16%) | 21 (35%) | 2.43 (1.25 to 4.73); P = 0.009 |
| Prostate 6 | 6 (2%) | 6 (10%) | 5.95 (1.71 to 20.73); P = 0.005 |
1Adjusted for age (<50, 50–59, 60–69, 70+) and sex.
2
Further adjusted for number of children (<2; 3 or more; missing).
3
Further adjusted for number of siblings (categories: <2; 3 or more; missing).
4
Among 60 years old and older , Ncontrols = 189; Ncases = 49.
5
Further adjusted for family size (using the total number of children and siblings; categories: <6; 6 or more; missing).
6
Further adjusted for number of brothers (<3; 3 or more; missing).
Ref: reference group; N: number; OR: Odds ratio; CI: confidence interval; SD: standard deviation.