Figure 2.

Determining the validity of the heuristic CME. Scheme illustrating the analytical approach to determine the validity of the heuristic CME which is used in this article. Parameters are chosen such that the deterministic QSSA is valid and such that molecule numbers are not too small. The LNA is applied to the heuristic CME leading to a linear FPE, describing the noise of the slow species. A different reduced linear FPE describing the noise in the slow species is obtained by applying a rigorous adiabatic elimination method on the linear FPE which approximates the CME of the full network. The noise statistics from the two linear FPEs are compared