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Effect of cisplatin concentration on caspase activity and apoptosis. (A, B) Relationship between apoptosis and various concentrations of cisplatin. Cisplatin induces dose-dependent apoptosis. C, D, and E show the activation of caspase-8, -3, and −9, respectively, with increasing doses of cisplatin for 24 h. (F) Effect of apoptosis by each pathway.
