Table 3.

Descriptions of reactions

Descriptions of reactions
I.	II-2.
$\begin{array}{c}Cisplatin+OCT2\stackrel{k_1^{+}}{\to }AquatedCis\hfill \\ AquatedCis+FasL\stackrel{k_{32}^{+}}{\to }Fas{L}^{*}\hfill \\ Fas{L}^{*}+Casp8\stackrel{k_{33}^{+}}{\underset{k_{33}^{-}}{\rightleftarrows }}Fas{L}^{*}\cdot Casp8\stackrel{k_{34}^{+}}{\to }Casp{8}^{*}\hfill \\ Casp{8}^{*}+Casp3\stackrel{k_{35}^{+}}{\underset{k_{35}^{-}}{\rightleftarrows }}Casp{8}^{*}\cdot Casp3\stackrel{k_{36}^{+}}{\to }\hfill \\ Casp{8}^{*}+Casp{3}^{*}\stackrel{k_{37}^{+}}{\to }Apop\hfill \\ Casp{3}^{*}+IAP\stackrel{k_{13}^{+}}{\underset{k_{13}^{-}}{\rightleftarrows }}Casp{3}^{*}\cdot IAP\hfill \end{array}$	$\begin{array}{c}Cisplatin+OCT2\stackrel{k_1^{+}}{\to }AquatedCis\hfill \\ AquatedCis+Mit\stackrel{k_{29}^{+}}{\to }{}_{\mathit{mit}}Ros\hfill \\ {}_{\mathit{mit}}Ros+{}_{\mathit{mit}}PTP\stackrel{k_{30}^{+}}{\to }{}_{\mathit{mit}}PT{P}^{*}\hfill \\ {}_{\mathit{mit}}PT{P}^{*}+Cytc{}_{\mathit{mit}}\stackrel{k_{31}^{+}}{\to }{}_{\mathit{mit}}PT{P}^{*}+Cytc\hfill \\ Cytc+Casp9\stackrel{k_{27}^{+}}{\underset{k_{27}^{-}}{\rightleftarrows }}Cytc\cdot Casp9\stackrel{k_{28}^{+}}{\to }Casp{9}^{*}\hfill \\ Casp{9}^{*}+Casp3\stackrel{k_9^{+}}{\underset{k_9^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot Casp3\stackrel{k_{10}^{+}}{\to }\hfill \\ Casp{9}^{*}+Casp{3}^{*}\stackrel{k_{11}^{+}}{\to }Apop\hfill \\ Casp{9}^{*}+IAP\stackrel{k_{12}^{+}}{\underset{k_{12}^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot IAP\hfill \\ Casp{3}^{*}+IAP\stackrel{k_{13}^{+}}{\underset{k_{13}^{-}}{\rightleftarrows }}Casp{3}^{*}\cdot IAP\hfill \end{array}$
II-1.	III.
$\begin{array}{c}Cisplatin+OCT2\stackrel{k_1^{+}}{\to }AquatedCis\hfill \\ AquatedCis+DNA\stackrel{k_{14}^{+}}{\to }DN{A}_{\mathit{damage}}\hfill \\ DN{A}_{\mathit{damage}}+ATR\stackrel{k_{15}^{+}}{\to }AT{R}^{*}\hfill \\ AT{R}^{*}+P53\stackrel{k_{16}^{+}}{\underset{k_{16}^{-}}{\rightleftarrows }}AT{R}^{*}\cdot P53\stackrel{k_{17}^{+}}{\to }P{53}^{*}\hfill \\ P{53}^{*}+Casp2\stackrel{k_{18}^{+}}{\underset{k_{18}^{-}}{\rightleftarrows }}P{53}^{*}\cdot Casp2\stackrel{k_{19}^{+}}{\to }P{53}^{*}+Casp{2}^{*}\hfill \\ Casp{2}^{*}+AI{F}_{\mathit{mit}}\stackrel{k_{20}^{+}}{\to }Casp{2}^{*}+AIF\stackrel{k_{21}^{+}}{\to }Apop\hfill \\ P{53}^{*}+Bax\stackrel{k_{22}^{+}}{\underset{k_{22}^{-}}{\rightleftarrows }}P{53}^{*}\cdot Bax\stackrel{k_{23}^{+}}{\to }Bax\cdot Bak\hfill \\ Bcl2+Bax\stackrel{k_{24}^{+}}{\underset{k_{24}^{-}}{\rightleftarrows }}Bcl2\cdot Bax\hfill \\ P{53}^{*}+Bcl2\stackrel{k_{25}^{+}}{\underset{k_{25}^{-}}{\rightleftarrows }}P{53}^{*}\cdot Bcl2\hfill \\ Bax\cdot Bak+Cyt{c}_{\mathit{mit}}\stackrel{k_{26}^{+}}{\to }Bax\cdot Bak+Cytc\hfill \\ Cytc+Casp9\stackrel{k_{27}^{+}}{\underset{k_{27}^{-}}{\rightleftarrows }}Cytc\cdot Casp9\stackrel{k_{28}^{+}}{\to }Casp{9}^{*}\hfill \\ Casp{9}^{*}+Casp3\stackrel{k_9^{+}}{\underset{k_9^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot Casp3\stackrel{k_{10}^{+}}{\to }\hfill \\ Casp{9}^{*}+Casp{3}^{*}\stackrel{k_{11}^{+}}{\to }Apop\hfill \\ Casp{9}^{*}+IAP\stackrel{k_{12}^{+}}{\underset{k_{12}^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot IAP\hfill \\ Casp{3}^{*}+IAP\stackrel{k_{13}^{+}}{\underset{k_{13}^{-}}{\rightleftarrows }}Casp{3}^{*}\cdot IAP\hfill \end{array}$	$\begin{array}{c}Cisplatin+OCT2\stackrel{k_1^{+}}{\to }AquatedCis\hfill \\ AquatedCis+ER\stackrel{k_2^{+}}{\to }C{a}^{2+}\hfill \\ C{a}^{2+}+Calpain\stackrel{k_3^{+}}{\underset{k_3^{-}}{\rightleftarrows }}C{a}^{2+}\cdot Calpain\stackrel{k_4^{+}}{\to }Calpai{n}^{*}\hfill \\ Calpai{n}^{*}+Casp12\stackrel{k_5^{+}}{\underset{k_5^{-}}{\rightleftarrows }}Calpai{n}^{*}\cdot Casp12\stackrel{k_6^{+}}{\to }Casp{12}^{*}\hfill \\ Casp{12}^{*}+Casp9\stackrel{k_7^{+}}{\underset{k_7^{-}}{\rightleftarrows }}Casp{12}^{*}\cdot Casp9\stackrel{k_8^{+}}{\to }Casp{12}^{*}+Casp{9}^{*}\hfill \\ Casp{9}^{*}+Casp3\stackrel{k_9^{+}}{\underset{k_9^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot Casp3\stackrel{k_{10}^{+}}{\to }Casp{9}^{*}+Casp{3}^{*}\stackrel{k_{11}^{+}}{\to }Apop\hfill \\ Casp{9}^{*}+IAP\stackrel{k_{12}^{+}}{\underset{k_{12}^{-}}{\rightleftarrows }}Casp{9}^{*}\cdot IAP\hfill \\ Casp{3}^{*}+IAP\stackrel{k_{13}^{+}}{\underset{k_{13}^{-}}{\rightleftarrows }}Casp{3}^{*}\cdot IAP\hfill \end{array}$

k⁺, forward rate constant of reaction; k^–, reverse rate constant of reaction; Casp12*, activated caspase-12.