View full-text article in PMC BMC Syst Biol. 2012 Sep 11;6:122. doi: 10.1186/1752-0509-6-122 Search in PMC Search in PubMed View in NLM Catalog Add to search Copyright and License information Copyright ©2012 Hong et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMC Copyright notice Table 4. Ordinary differential equation Ordinary differential equations dAqcis/dt=k1+CisOCT2dCa2+/dt=k2+AqcisER−k3+Ca2+Calpain+k3−Ca2+⋅CalpaindCalpain/dt=−k3+Ca2+Calpain+k3−Ca2+⋅CalpaindCa2+⋅Calpain/dt=k3+Ca2+Calpain+k3−Ca2+⋅Calpain−k4+Ca2+⋅CalpaindCalpain*/dt=k4+Ca2+⋅Calpain−k5+Calpain*Casp12+k5−Calpain*⋅Casp12dCasp12/dt=−k5+Calpain*Casp12+k5−Calpain*⋅Casp12dCalpain*⋅Casp12/dt=k5+Calpain*Casp12−k5−Calpain*⋅Casp12−k6+Calpain*⋅Casp12dCasp12*/dt=k6+Calpain*⋅Casp12−k7+Casp12*Casp9+k7−Casp12*⋅Casp9dCasp9/dt=−k7+Casp12*Casp9+k7−Casp12*⋅Casp9−k27+CytcCasp9+k27−Cytc⋅Casp9dCasp12*⋅Casp9/dt=k7+Casp12*Casp9−k7−Casp12*⋅Casp9−k8+Casp12*⋅Casp9dCasp9*/dt=k8+Casp12*⋅Casp9+k9−Casp9*⋅Casp3−k9+Casp9*Casp3−k12+Casp9*IAP+k12−Casp9*⋅IAP+k28+Cytc⋅Casp9 dATR*/dt=k15+DNAdamageATR−k16+ATR*P53+k16−ATR*⋅P53dP53/dt=k16+ATR*P53+k16−ATR*⋅P53dATR*⋅P53/dt=k16+ATR*P53−k16−ATR*⋅P53−k17+ATR*⋅P53dP53*/dt=k17+ATR*⋅P53+k18−P53*⋅Casp2−k18+P53*Casp2−k22+P53*Bax+k22−P53*⋅Bax−k25−P53*Bcl2+k25−P53*⋅Bcl2dCasp2/dt=−k18+P53Casp2+k18−P53*⋅Casp2dP53*⋅Casp2/dt=k18+P53*Casp2−k18-P53*⋅Casp2−k18-P53*⋅Casp2dCasp2/dt=k19+P53Casp2−k20+Casp2*AIFmitdAIFmit/dt=−k20+Casp2*AIFmitdAIF/dt=k20+Casp2*AIFmitdBax/dt=-k22+P53*Bax+k22-P53*⋅Bax dCasp3*/dt=k10+Casp9*⋅Casp3+k36+Casp8*⋅Casp3−k13+Casp3*IAP+k13−Casp3*⋅IAPdIAP/dt=−k12+Casp9*IAP+k12−Casp9*⋅IAP−k13+Casp3*IAP+k13−Casp3*⋅IAPdCasp9*⋅IAP/dt=k12+Casp9*IAP−k12−Casp9*⋅IAPdCasp3*⋅IAP/dt=k13+Casp3*IAP−k13−Casp3*⋅IAPdDNAdamage/dt=k14+AgcisDNA dP53*⋅Bax/dt=k22+P53*Bax−k22−P53*⋅Bax−k23−P53*⋅BaxdBax⋅Bak/dt=k23+P53*⋅BaxdBcl2/dt=−k25+P53*Bcl2+k25−P53*⋅Bcl2−k24+Bcl2Bax+k24−Bcl2⋅BaxdP53*⋅Bcl2/dt=k25+P53*Bcl2−k25−P53*⋅Bcl2dBcl2⋅Bax/dt=k24+Bcl2Bax−k24−Bcl2⋅Bax dmitRos/dt=k29+AqcisMitdmitPTP*/dt=k30+mitRosmitPTPdCytcmit/dt=−k26+Bax⋅BakCytcmit−k31+mitPTP*CytcmitdCyct/dt=k26+Bax⋅BakCytcmit−k27+CytcCasp9+k27−Cytc⋅Casp9+k31+mitPTP*CytcmitdCytc⋅Casp9/dt=k27+CytcCasp9−k27−Cytc⋅Casp9−k28+Cytc⋅Casp9dFasL*/dt=k32+AqcisFasL−k33+FasL*Casp8+k33−FasL*⋅Casp8dCasp8/dt=−k33+FasL*Casp8+k33−FasL*⋅Casp8−k34+FasL*⋅Casp8 dFasL*⋅Casp8/dt=k33+FasL*Casp8−k33-FasL*⋅Casp8−k34+FasL*⋅Casp8dCasp8*/dt=k34+FasL*⋅Casp8−k35+Casp8*Casp3+k35-Casp8*⋅Casp3dCasp8*⋅Casp3dt=k35+Casp8*Casp3−k35-Casp8*⋅Casp3−k36+Casp8*⋅Casp3dApop/dt=k11+Casp9*Casp3*+k21+Casp2*AIF+k37+Casp8*Casp3*