Table 1. DNA repair genes transcriptionally modulated in LCLs at 4 hr post-IR (p<0.05).

Gene	Rank	Total gene rank	Fold change	p-value	DNA repair pathway
XPC	1	17	2	1.4E−10	Nucleotide excision repair
POLH	2	42	2.2	8.2E−09	DNA polymerases (catalytic subunits)
DDB2	3	48	1.7	2.3E−08	Nucleotide excision repair
PCNA	4	54	1.5	4.6E−08	DNA polymerases (catalytic subunits)
RRM2B	5	69	1.8	2.1E−07	Modulation of nucleotide pools
REV3L	6	204	1.3	0.0001	DNA polymerases (catalytic subunits)
LIG1	7	298	1.2	0.0005	Nucleotide excision repair
APTX	8	383	1.2	0.001	Editing and processing nucleases
TDP1	9	411	−1.2	0.002	Repair of DNA-protein crosslinks
H2AFX	10	512	−1.2	0.003	Chromatin Structure
CHAF1A	11	538	1.1	0.004	Chromatin Structure
MBD4	12	638	−1.2	0.006	Base excision repair
ATM	13	672	−1.2	0.007	Genes defective in diseases associated with sensitivity to DNA damaging agents
DCLRE1C	14	691	−1.2	0.007	Non-homologous end-joining
RAD51C	15	696	1.4	0.007	Homologous recombination
RAD51	16	729	1.2	0.009	Homologous recombination
EXO1	17	850	1.2	0.013	Editing and processing nucleases
RAD51L3	18	946	1.1	0.018	Homologous recombination
PALB2	19	963	1.1	0.018	Genes defective in diseases associated with sensitivity to DNA damaging agents
MDC1	20	1179	−1.1	0.030	Other conserved DNA damage response genes
RECQL4	21	1403	1.1	0.042	Genes defective in diseases associated with sensitivity to DNA damaging agents