Table 4.
Most significant affected IPA canonical pathways
| Canonical pathway (IPA) | Genes | P-value | Ratio |
|---|---|---|---|
| T4 |
|
|
|
| MIF-mediated Glucocorticoid Regulation |
TLR4, NFKBIA, CD14, PTGS2, NFKBIB, NFKB1 |
4.67E-06 |
6/41 |
| MIF Regulation of Innate Immunity |
TLR4, NFKBIA, CD14, PTGS2, NFKBIB, NFKB1 |
1.8E-05 |
6/49 |
| NF-κB Signalling |
TLR4, IL1A, TGFBR1, RIPK1, NFKBIA, MYD88, BMP2, RELB, TNFAIP3, NFKBIB, NFKB1 |
2.46E-05 |
11/176 |
| IL-10 Signalling |
IL18RAP, IL1A, NFKBIA, CD14, ARG2, NFKBIB, NFKB1 |
4.47E-05 |
7/78 |
| Hypoxia Signalling in the Cardiovascular System |
HSP90B1, UBE2H (includes EG:7328), NFKBIA, UBE2B, HIF1A, NFKBIB, UBE2L6 |
5.4E-05 |
7/71 |
| T5 |
|
|
|
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages |
TLR4, PPP1R3D, NFKBIA, ARG2, NCF4, NFKB1, RHOH, IRF1, SIRPA |
1.98E-06 |
9/189 |
| LXR/RXR Activation |
TLR4, IL18RAP, FASN, CD14, ARG2, NFKB1 |
1.85E-05 |
6/93 |
| Toll-like Receptor Signalling |
TLR4, NFKBIA, MYD88, CD14, NFKB1 |
2.72E-05 |
5/55 |
| Acute Phase Response Signalling |
SOD2, C3, NFKBIA, MYD88, OSM, SERPINA1, NFKB1, SAA1 |
3.59E-05 |
8/183 |
| MIF-mediated Glucocorticoid Regulation | TLR4, NFKBIA, CD14, NFKB1 | 8.09E-05 | 4/41 |
Five most significant canonical pathways identified with IPA using the significantly affected genes for T4 and T5. The identified canonical pathways are listed from the lowest to the highest p-value, and are reported with the involved genes and the corresponding ratio (# of genes involved/ # of known genes in the pathway).