Table 1.
CYP enzymes in humans, rat, mouse, dog and monkey
| CYP 450 enzyme | ||||||
|---|---|---|---|---|---|---|
|
Family |
Subfamily |
Gene |
||||
| |
Human |
Monkey |
Dog |
Rat |
Mouse |
|
| 1 |
A |
1, 2 |
1, 2 |
1, 2 |
1, 2 |
1, 2 |
| 2 |
A |
6, 7, 13 |
23, 24 |
13, 25 |
1, 2, 3 |
4, 5, 12, 22 |
| 2 |
B |
6 |
17 |
11 |
1-3, 8, 12, 15, 21 |
9, 10, 13, 19, 23 |
| 2 |
C |
8, 9, 18, 19 |
20, 74, 75, 76 |
21, 41 |
6, 7, 11–13, 22–24, 46 |
29, 37–40, 44, 50 |
| 2 |
D |
6 |
1, 7, 42 |
15 |
1-5, 18 |
9-13, 22, 26, 34, 40 |
| 2 |
E |
1 |
1 |
1 |
1 |
1 |
| 3 | A | 4, 5, 7, 43 | 6, 8, 64, 66 | 12, 26 | 1, 2, 9, 18, 23, 62 | 11, 13, 16, 25, 41, 44, 57, 59 |
Cytochrome P450 (CYP) is a superfamily of enzymes and are the major drug-metabolizing enzymes.
CYP enzymes are categorized as CYP letter_number_letter. The first number is the gene family, the letter is the subfamily, and the final number is the individual gene. Some subfamilies have enzymes from several different genes. (Adopted and based on data from [58-60]).