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. 2012 Nov 29;13:115. doi: 10.1186/1471-2350-13-115

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Copyright ©2012 Wu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interactive effect of MMP9 levels on the association between rs10800469 and sE-selectin levels. After adjusting for clinical covariates, minor allele of rs10800469 of the SELE gene was found to be associated with decreased sE-selectin levels, predominantly in highest quartile of MMP9 levels subjects (P = 0.002). Interaction analysis revealed an interaction of MMP9 levels with the rs10800469 genotype (interaction P = 0.023, after the adjustment of age, gender, BMI, smoking, sICAM1 and MMP9).