Table 3.
Association of SELE locus haplotypes with MMP9 level (adjusted for age, gender, BMI, and smoking)
| SNP1 | SNP 2 | SNP 3 | SNP 4 | SNP 5 | SNP 6 | SNP 7 | Frequency | Coef | SE | P value | Adjusted P value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H1 |
A |
A |
A |
A |
A |
G |
C |
0.2542 |
-0.0514 |
0.0227 |
0.0234 |
0.0819 |
| H2 |
G |
G |
A |
G |
A |
G |
T |
0.2266 |
0.0512 |
0.0190 |
0.0070 |
0.0490 |
| H3 |
G |
G |
A |
G |
C |
G |
C |
0.2080 |
-0.0112 |
0.0200 |
0.5746 |
0.8044 |
| H4 |
A |
A |
A |
G |
A |
A |
C |
0.1384 |
0.0144 |
0.0221 |
0.5144 |
0.9002 |
| H5 |
G |
A |
A |
G |
A |
G |
C |
0.0651 |
-0.0086 |
0.0310 |
0.7822 |
0.7822 |
| H6 |
A |
A |
A |
G |
A |
G |
C |
0.0592 |
-0.0261 |
0.0352 |
0.4572 |
1 |
| H7 | G | G | A | G | A | G | C | 0.0484 | -0.0167 | 0.0370 | 0.6524 | 0.7611 |
SNP1: rs10800469, SNP2: rs3917406, SNP3: rs5361, SNP4: rs3917412, SNP5: rs2179172, SNP6: rs3917419, SNP7:rs5368. Multiple linear regression, adjusted for age, gender, smoking and BMI. Adjusted P values were computed by the false discovery rate method.