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. 2012 Dec 28;7(12):e53154. doi: 10.1371/journal.pone.0053154

Figure 8. SPX has little effect on the infiltration of macrophages in islets of IL-10-deficient mice.

Figure 8

(A and B) Representative images of CD11c staining (A) and CD206 staining (B) in intra-islet areas of pancreas sections from each group. Scale bar = 100 µm. (C−E) CD11c-positive areas (C), CD206-positive areas (D), and M1/M2 ratios (E) in the islets in each group (n = 6). *P<0.05 vs. the Sham group (wild-type or IL-10KO mice), # P<0.05 vs. SPX mice (wild-type). Treatment groups: Sham, fed a HF diet, given serum albumin, and sham-operated; SPX, fed a HF diet, given serum albumin, and splenectomized; SPX+IL-10, fed a HF diet, given recombinant mouse IL-10, and splenectomized. Wild-type, wild-type mice; IL-10KO, IL-10-deficient mice.