Table 4.

Functional Annotation Clustering of statistically-significant over-expressed genes in European eel silver males from the river Tiber site (N = 8) in comparison with silver males from the lake Bolsena site (N = 7)

Annotation Cluster	Gene
Annotation Cluster 1	Cytochrome c oxidase subunit 1
(Enrichment Score: 1.81)	Cytochrome P450, family 2 subfamily J, polypeptide 23 (CYP2J23)
	Cytochrome P450, family 3 subfamily A, polypeptide 65 (CYP3A65)
	Cytochrome P450, family 46 subfamily A, polypeptide 61 (CYP46A1)
	Glutamate dehydrogenase 1a
	Glutathione peroxidase 1a
	Retinol saturase (all-trans-retinol 13,14-reductase)
	SH3 domain binding glutamic acid-rich protein like 3
	Sulfide quinone reductase-like
	Transferrin-a, Rho-class gluthatione S-transferase
Annotation Cluster 2	Pi-class glutathione-S-transferase
(Enrichment Score: 1.53)	Glutathione peroxidase 1a
	SH3 domain binding glutamic acid-rich protein like 3
	Transferrin receptor 1a
	Transferrin -a: Rho-class glutathione-S-transferase