Table 1.
DASE Candidate Loci Identified by both SNP- and Gene-based Approaches.*
|
Gene_ID |
SNP |
SNP-based |
Gene-based |
||||
|---|---|---|---|---|---|---|---|
| DASE | P-Value | FDR | DASE | P-Value | FDR | ||
|
ACPP |
rs14192 |
3.83 |
0.010497 |
0.0442 |
2.32 |
0.005517 |
0.0216 |
|
ADAMTSL3 |
rs2277849 |
3.13 |
0.007309 |
0.0359 |
2.25 |
0.014546 |
0.0280 |
|
AGBL1 |
rs10520618 |
3.12 |
0.000134 |
0.0279 |
2.37 |
0.000305 |
0.0113 |
|
C1orf94 |
rs6698707 |
3.27 |
0.000023 |
0.0016 |
3.27 |
0.000024 |
0.0088 |
|
CEP170P1 |
rs28720014 |
3.59 |
0.002355 |
0.0180 |
3.59 |
0.002355 |
0.0282 |
|
CHRAC1 |
rs10216653 |
4.31 |
0.007459 |
0.0360 |
4.31 |
0.007459 |
0.0425 |
|
CTAGE11P |
rs477274 |
2.42 |
0.003269 |
0.0237 |
2.42 |
0.003269 |
0.0319 |
|
DMBT1 |
rs11523871 |
2.03 |
0.001676 |
0.0140 |
2.03 |
0.001676 |
0.0268 |
|
FAM154B |
rs16973457 |
2.03 |
0.002254 |
0.0423 |
2.03 |
0.002254 |
0.0427 |
|
FLJ39061 |
rs10221698 |
4.01 |
0.008501 |
0.0379 |
4.01 |
0.008501 |
0.0442 |
|
FLJ42393 |
rs344952 |
2.04 |
0.000490 |
0.0449 |
2.25 |
0.000012 |
0.0093 |
|
GRIN3A |
rs10989563 |
3.78 |
0.001589 |
0.0385 |
3.25 |
0.001386 |
0.0364 |
|
GRK4 |
rs1024323 |
2.37 |
0.000845 |
0.0532 |
2.71 |
0.000261 |
0.0113 |
| |
rs2960306 |
3.01 |
0.000014 |
0.0053 |
- |
- |
- |
|
HCG4 |
rs1611213 |
2.19 |
0.003925 |
0.0257 |
2.16 |
0.005494 |
0.0098 |
|
HLA-G |
rs1130363 |
2.52 |
0.001700 |
0.0399 |
3.49 |
0.002469 |
0.0170 |
|
HNRNPKP1 |
rs182844 |
2.53 |
0.000285 |
0.0071 |
2.53 |
0.000285 |
0.0113 |
|
HS6ST1P1 |
rs6423191 |
4.73 |
0.000005 |
0.0002 |
4.73 |
0.000005 |
0.0005 |
|
KHSRPP1 |
rs12380505 |
2.27 |
0.001212 |
0.0342 |
2.27 |
0.001212 |
0.0364 |
|
LAP3P2 |
rs12199346 |
3.55 |
0.000007 |
0.0010 |
3.21 |
0.000250 |
0.0113 |
|
LOC283398 |
rs7139313 |
3.74 |
0.000001 |
0.0003 |
2.58 |
0.003455 |
0.0178 |
|
LOC341056 |
rs7933723 |
3.70 |
0.002423 |
0.0423 |
3.70 |
0.002423 |
0.0428 |
|
LOC387703 |
rs7070947 |
3.61 |
0.000854 |
0.0305 |
3.61 |
0.000854 |
0.0355 |
|
LOC440973 |
rs605795 |
2.79 |
0.002160 |
0.0423 |
2.79 |
0.002160 |
0.0427 |
|
LOC442238 |
rs985937 |
4.13 |
0.000168 |
0.0114 |
4.13 |
0.000168 |
0.0152 |
|
LOC642590 |
rs9455190 |
3.66 |
0.000645 |
0.0486 |
2.50 |
0.000915 |
0.0355 |
|
LOC643618 |
rs732531 |
3.79 |
0.009696 |
0.0417 |
3.12 |
0.012274 |
0.0268 |
|
LOC645521 |
rs1976809 |
4.11 |
0.000052 |
0.0091 |
4.11 |
0.000052 |
0.0128 |
|
LOC646970 |
rs614805 |
3.38 |
0.008546 |
0.0379 |
3.09 |
0.004693 |
0.0207 |
|
LOC727884 |
rs12371762 |
5.21 |
0.002386 |
0.0423 |
4.76 |
0.000009 |
0.0002 |
|
LOC729675 |
rs13137565 |
2.36 |
0.003844 |
0.0498 |
2.36 |
0.003844 |
0.0522 |
|
MAGEC2 |
rs3765272 |
3.30 |
0.000109 |
0.0091 |
3.30 |
0.000109 |
0.0128 |
|
MMP20 |
rs1784423 |
2.32 |
0.001136 |
0.0133 |
2.25 |
0.001791 |
0.0268 |
|
MUC16 |
rs2547068 |
3.88 |
0.012106 |
0.0462 |
2.61 |
0.003190 |
0.0072 |
|
MYADML |
rs11684598 |
5.97 |
0.000167 |
0.0114 |
5.97 |
0.000167 |
0.0152 |
|
NLRP1 |
rs11651270 |
2.39 |
0.013058 |
0.0479 |
2.87 |
0.000835 |
0.0105 |
|
NSUN4 |
rs17361749 |
2.43 |
0.000076 |
0.0091 |
2.43 |
0.000076 |
0.0128 |
|
OR13H1 |
rs17316625 |
3.12 |
0.003801 |
0.0498 |
3.12 |
0.003801 |
0.0522 |
|
OR6N1 |
rs857825 |
2.78 |
0.002543 |
0.0431 |
2.44 |
0.002721 |
0.0443 |
| |
rs857826 |
3.98 |
0.000430 |
0.0449 |
- |
- |
- |
|
PHF2P1 |
rs9553323 |
5.08 |
0.000053 |
0.0021 |
4.47 |
0.000252 |
0.0048 |
|
PRDM14 |
rs10089937 |
2.07 |
0.002243 |
0.0423 |
2.07 |
0.002243 |
0.0427 |
|
PTCHD3 |
rs2484173 |
4.13 |
0.002351 |
0.0423 |
3.00 |
0.000427 |
0.0128 |
|
PTTG2 |
rs6811863 |
3.06 |
0.001091 |
0.0342 |
3.06 |
0.001091 |
0.0364 |
|
RPL4P4 |
rs13099317 |
4.43 |
0.000063 |
0.0011 |
4.43 |
0.000063 |
0.0044 |
|
RPL9P16 |
rs7439293 |
3.44 |
0.001159 |
0.0133 |
3.06 |
0.003857 |
0.0329 |
|
SLAMF1 |
rs1061217 |
3.42 |
0.000524 |
0.0085 |
3.42 |
0.000524 |
0.0137 |
|
SMARCE1P3 |
rs11852150 |
3.46 |
0.000020 |
0.0016 |
2.97 |
0.000543 |
0.0137 |
|
SZT2 |
rs2027130 |
2.72 |
0.000478 |
0.0085 |
2.39 |
0.003010 |
0.0313 |
|
TARDBPP2 |
rs9528094 |
4.81 |
0.000122 |
0.0279 |
2.46 |
0.009678 |
0.0454 |
|
TEX34 |
rs11651968 |
2.60 |
0.001264 |
0.0135 |
2.60 |
0.001264 |
0.0252 |
|
TLK2P1 |
rs3744516 |
4.00 |
0.004876 |
0.0516 |
4.78 |
0.000203 |
0.0046 |
| |
rs4795846 |
5.84 |
0.000008 |
0.0053 |
- |
- |
- |
|
TMCC3 |
rs1290005 |
3.45 |
0.002658 |
0.0198 |
2.10 |
0.005092 |
0.0209 |
|
UFM1 |
rs2485783 |
3.96 |
0.000659 |
0.0082 |
3.96 |
0.000659 |
0.0100 |
|
UQCRFS1P2 |
rs13238715 |
3.95 |
0.000097 |
0.0091 |
3.02 |
0.003106 |
0.0177 |
|
USP6 |
rs11658877 |
4.80 |
0.001324 |
0.0135 |
4.54 |
0.000530 |
0.0086 |
|
WASF4 |
rs909713 |
4.10 |
0.000063 |
0.0091 |
4.07 |
0.000076 |
0.0128 |
|
WNT3A |
rs752107 |
3.04 |
0.000037 |
0.0020 |
3.04 |
0.000037 |
0.0088 |
|
XIAP |
rs5958343 |
2.46 |
0.005591 |
0.0327 |
2.27 |
0.006924 |
0.0423 |
|
XPNPEP2 |
rs3747343 |
2.55 |
0.000343 |
0.0073 |
2.55 |
0.000343 |
0.0113 |
|
ZBTB8OS |
rs3753603 |
3.31 |
0.004053 |
0.0259 |
3.31 |
0.004053 |
0.0329 |
| ZNF331 | rs8110350 | 2.31 | 0.001826 | 0.0403 | 2.48 | 0.001014 | 0.0121 |
*: Only loci with DASE ≥ 2; P ≤ 0.01; and FDR ≤ 0.05 were included.