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. 2012 Dec 28;7(12):e50946. doi: 10.1371/journal.pone.0050946

Table 1. Characteristics of the eligible studies.

First author (ref) Year Study design n (M/F) Tumor location Tumor stage I/II (III/IV) Median follow-up (y) Blinded reading Staining for TAM high RR estimation Analysis Result
Gastrointestinal cancer (N = 19)
Khorana (29) 2003 Prosp. 131 (69/53) 131 Colon 11 (118) 5 NR >2% Data extrapolated, Survival curve Stag., OS Indeterminate
Tan (12) 2005 Retro. 60 (35/25) 60 Colon 26 (34) NR NR >25% Data extrapolated, Survival curve Stag., OS Negative
Bacman (30) 2007 NR 310 (189/121) 310 Colon 178 (132) 7.5 NR NR Data extrapolated OS Indeterminate
Forssell (15) 2007 Retro. 488 (271/217) 488 Colon 207 (254) NR NR NR Data extrapolated, Reported in text Stag., OS Indeterminate, negative
Zhou (18) 2010 NR 160 (94/66) 160 Colon NR 5 Yes 20% Data extrapolated, reported in text Stag., OS Negative
Ishigami (31) 2003 Retro. 97 (72/25) 97 Stom 67 (30) NR NR >200 / HPF Data extrapolated, Survival curve Stag., OS Indeterminate, positive
Ohno (10) 2005 Retro. 84 (57/27) 84 Stom 41 (43) NR Yes >4.7% Survival curve DFS Negative
Hass (32) 2009 Prosp. 52 (40/12) 50 Stom 39 (13) 5.9 NR NR Reported in text DFS Indeterminate
Kawahara (33) 2010 NR 111 (77/34) 111 Stom 36 (75) NR NR NR Reported in text OS Positive
Osinsky (34) 2011 Prosp. 105 (71/34) 105 stom 48 (57) NR NR >23.0% Reported in text OS Positive
Zhu (22) 2008 Retro. 105 (96/9) 105 Liver 86 (19) 1.84 NR >20% Data extrapolated, reported in text Stag., OS, DFS Indeterminate, positive
Li (24) 2009 Retro. 302 (260/42) 302 Liver 237 (65) 4.83 NR >20% Data extrapolated, reported in text Stag., OS, DFS Indeterminate, negative
Ding (35) 2009 Retro. 107 (87/20) 107 Liver 98 (39) 2.5 MR >23% Reported in text OS, DFS Positive
Kuang (36) 2009 Retro. 262 (NR) 206 Liver 249 (13) NR NR NR Reported in text OS, DFS Positive
Ju (23) 2009 Retro. 130 (112/18) 130 Liver 66 (64) 2.65 NR >20% Reported in text Stag., OS, DFS Positive
Koide (9) 2002 Retro. 56 (42/14) 56 Esophagus 30 (26) NR NR NR Data extrapolated, survival cure Stag., OS Indeterminate, negative
Guo (19) 2007 NR 137 (103/34) 137 Esophagus 86 (51) NR NR >25% Reported in text Stag., OS Indeterminate, positive
Kurahara (37) 2012 Retro. 76 (52/24) 52 Pancreas 29 (47) NR Yes NR Survival curve OS, OSb Indeterminate
Hasita (38) 2010 NR 39 (27/12) 55 Bile duct 29 (10) 3.33 Yes NR Data extrapolated, survival curve Stag., OS, DFS, Stag.b, OSb, DFSb Indeterminate
Urogenital cancer (N = 20)
Leek (39) 1996 Retro. 101 (0/101) 5 Breast NR NR NR MD > = 12 Reported in text OS, DFS Positive
Toi (40) 1999 NR 229 (0/229) 229 Breast NR 4 Yes NR Survival curve DFS Indeterminate
Valkovic (41) 2002 NR 97 (0/97) 97 Breast 82 (15) NR NR NR Data extrapolated Stag. Indeterminate
Bolat (42) 2006 Retro. 78 (0/78) 78 Breast 38 (10) NR NR NR Data extrapolated Stag. Indeterminate
Mahmound (43) 2012 Retro. 1902 (0/1902) 1902 Breast 220 (1682) NR NR NR Data extrapolated, survival curve Stag., DFS Positive, indeterminate
Salvesen (44) 1999 Prosp. 60 (0/60) 60 Endometrium 50(10) 11 NR NR Data extrapolated, reported in text Stag., OS Positive, indeterminate
Hashimoto (45) 2000 NR 109 (0/109) 109 Endometrium 56(53) 4.58 NR NR Data extrapolated Stag., DFS Indeterminate
Ohno (11) 2004 Retro. 70 (0/70) 70 Endometrium NR NR NR MD >10.7 Survival curve DFS Negative
Soeda (46) 2008 Retro. 76 (0/76) 76 Endometrium 59(17) 6.83 NR NR Survival curve OS, DFS Positive, indeterminate
Espinosa (47) 2010 NR 64 (0/64) 64 Endometrium 23(26) NR NR NR Data extrapolated Stag.b Indeterminate
Lissbrant (48) 2000 Retro. 85 (85/0) 85 Prostate 75(10) NR NR > = 0.97% Survival curve Stag., OS Indeterminate
Shimura (49) 2000 NR 81 (81/0) 81 Prostate 67(13) 3.9 NR NR Reported in text DFS Indeterminate
Nonomura (50) 2011 NR 131 (131/0) 131 Prostate 30(41) 2.9 NR MD > = 22 Survival curve DFS Positive
Heller (51) 2002 Retro. 24 (0/24) 24 Cervix 20/4 NR NR NR Data extrapolated Stag. Indeterminate
Kawanaka (52) 2008 Retro 73 (0/73) 73 Cervix 22/51 NR Yes MD > = 55 Survival curve DFS Indeterminate
Hanada (53) 2000 NR 63 (51/12) 63 Bladder 42/21 5.4 Yes MD > = 67 Data extrapolated, reported in text Stag., OS Positive
Takayama (54) 2009 NR 41 (38/3) 41 Bladder NR 25 NR > = 4 Reported in text DFS Positive
Tanaka (55) 2004 NR 89 (0/89) 89 Ovary 22/67 6.8 NR > = 25% Data extrapolated, reported in text, survival curve Stag., OS, DFS Negative, positive, indeterminate
Wan (25) 2009 NR 67 (0/67) 67 Ovary 0/67 NR NR >20% Survival curve OS Positive
Chai (20) 2008 NR 99 (42/57) 99 Uroth NR NR NR >20% Reported in text OS, DFS Indeterminate, positive
Lung cancer (N = 10)
Takanami (56) 1999 Retro. 113 (66/47) 113 Lung 61/52 NR NR MD>32 Survival curve OS Positive
Chen (57) 2005 NR 41 (27/14) 41 Lung 23/18 NR NR MD> = 163 Survival curve DFS Indeterminate
Welsh (13) 2005 Retro. 175 (116/59) 175 Lung 123/38 NR Yes NR Data extrapolated Stag., DFS Negative
Zeni (58) 2007 NR 50 (43/7) 43 Lung NR NR NR >16.3% Reported in text, survival curve Stag., OS Positive
Kawai (16) 2008 NR 199 (139/60) 199 Lung NR NR NR NR Reported in text OS Negative
Ohri (17) 2009 Retro. 40 (16/24) 40 Lung 34/6 NR NR NR Survival curve OS Negative
Al-shibli (59) 2009 Retro. 371 (253/82) 371 Lung 303/32 8 NR > = 25% Data extrapolated, survival curve OS, DFS Indeterminate
Ma (26) 2010 NR 50 (40/10) 50 Lung 33/17 NR NR >20% Reported in text OSa, OSb Indeterminate
Ohtaki (60) 2010 Prosp. 170 (85/85) 170 Lung NR 10.1 NR NR Data extrapolated Stag., OS Positive
Zhang (61) 2011 Retro. 65 (38/27) 65 Lung 38/27 NR Yes TAM counts >102 Survival curve OS Positive
Head and neck cancer (N = 4)
Liu (21) 2008 NR 112 (93/19) 112 Oral 50/62 NR NR >20% Data extrapolated, survival curve Stag., OS Positive
Fujii (62) 2012 NR 108 (31/10) 108 Oral 46/62 NR NR > = 2/HPF Data extrapolated, reported in text Stag., stag.b, OSb Positive, indeterminate, positive
Peng (14) 2006 NR 60 (38/22) 60 Oral 15/45 NR NR > = 63.7/HPF Data extrapolated OS Negative
Lin (63) 2011 NR 84 (77/7) 84 Lar 30/54 NR NR > = 10/HPF Data extrapolated, reported in text Stag., OS, DFS Indeterminate, indeterminate, positive
Thyroid cancer (N = 1)
Ryder (64) 2008 NR 37 (13/24) 37 Thyr 5/32 NR Yes > = 10/HPF Survival curve OS Positive
Mesothelioma (N = 1)
Burt (65) 2011 Retro. 667 (531/136) 667 Meso 64/603 NR Yes NR Reported in text OS Indeterminate