Figure 2. Atypical patterns of genetic differentiation observed for VKORC1 SNPs.

Genome-wide empirical distributions of F_ST values were constructed from 644,143 SNPs having a MAF ≥0.001 at the global level. Individual values of F_ST calculated for each of the seven VKORC1 SNPs are plotted against their global MAF. The functional rs9923231 SNP is shown in red. The 50^th, 95^th and 99^th percentiles are indicated as dotted, dashed and full red lines, respectively.