Table 1. Parameter configurations in the simulation studies.
| Sample size | Genetic effecta | ||||
| SNP1 | SNP2 | SNP3 | SNP1×SNP3 | ||
| Simulation 1 | 600 | 3.00% | 1.50% | 1.00% | 1.50% |
| 800 | 3.00% | 1.50% | 1.00% | 1.50% | |
| 1000 | 3.00% | 1.50% | 1.00% | 1.50% | |
| 2000 | 3.00% | 1.50% | 1.00% | 1.50% | |
| Simulation2 | 1000 | 1.00% | 0.50% | 0.25% | 0.50% |
| 1000 | 2.00% | 1.00% | 0.50% | 1.00% | |
| 1000 | 3.00% | 1.50% | 1.00% | 1.50% | |
| 1000 | 3.50% | 2.00% | 1.50% | 2.00% | |
| Simulation3 | 1000 | 2.00% | 1.00% | 0.50% | 1.00% |
| 1000 | 2.00% | 1.00% | 0.50% | 1.50% | |
| 1000 | 2.00% | 1.00% | 0.50% | 2.00% | |
| 1000 | 2.00% | 1.00% | 0.50% | 3.00% | |
a
denote the phenotypic variance explained by the additive genetic effects of SNP1, SNP2 and SNP3 as well as an interactive effect between SNP1 and SNP3, respectively.
333 pathways with sizes varying from 20 to 40, were collected from public pathway databases and used for pathway simulations.