Table 6.
ZO-1 immunohistochemistry and semiquantitative assessment of cell number and intensity of staining in small bowel and rectosigmoid mucosa in HLA-DQ2/8-positive and -negative groups
| IBS-D Patients |
Overall P Value | ||
|---|---|---|---|
| HLA-DQ2/8-positive (n = 13) | HLA-DQ2/8-negative (n = 15) | ||
| Small bowel | |||
| ZO-1, %cells | 60 ± 6.6 | 70.7 ± 5.0 | 0.23 |
| ZO-1 intensity score, no. of patients | |||
| Grade 1 | 3 | 1 | 0.06 |
| Grade 2 | 5 | 6 | |
| Grade 3 | 5 | 8 | |
| ZO-1, %cells × intensity | 141.5 ± 25.7 | 182.7 ± 20.6 | 0.24 |
| Rectosigmoid | |||
| ZO-1, %cells | 50.8 ± 6.7 | 63.1 ± 4.1 | 0.21 |
| ZO-1 intensity score, no. of patients | |||
| Grade 1 | 6 | 1 | 0.01 |
| Grade 2 | 4 | 8 | |
| Grade 3 | 2 | 4 | |
| ZO-1, %cells × intensity | 95.0 ± 21.8 | 146.2 ± 17.1 | 0.07 |