Fig. 1.

The construct used to generate dominant-negative fibroblast growth factor receptor (dnFGFR) mice. A 2.3-kb fragment of the rat gonadotropin-releasing hormone (GnRH) promoter (−2987 to −1172 appended to −441 to +104) was used to drive the expression of a dnFGFR, which is the IIIc variant of FGFR1 lacking the intracellular tyrosine kinase domain. A rabbit β-globin intron (intron) and human growth hormone polyadenylation signal (polyA) were placed upstream and downstream of dnFGFR, respectively, to facilitate transgene expression and processing.