Table 2.

Phosphorylation and cell surface expression of NCC

Experimental Model	Stimulus	Phosphorylation/Activity	Surface Expression	Reference No(s).
Xenopus oocytes	Intracellular chloride depletion	↑↑	⇆	65
Xenopus oocytes	Protein phosphatase 4	↓↓	⇆	32
Xenopus oocytes	WNK3	↑↑↑	↑↑↑	66, 73, 97
Xenopus oocytes	Mutant NCC-T58D	↑↑	⇆	32
Xenopus oocytes	Mutant NCC-T58A	↓↓	⇆	32, 65
Mouse	WNK4(D561A/+) knockin	↑↑	↑↑	99
Brattleboro rats	dDAVP	↑↑	↑↑ (no shift)	67
Brattleboro rats/Wistar rats	dDAVP	↑↑	↑↑ (shift)	60
Mouse	SPAK knockout	↓↓	?	98
Mouse	SPAK knockout	↓↓	?	54