Table 1. Transcripts regulated by Notch ligand intracellular domains.
transcript | fold change | description | ||
DLL1-ICD regulated | ||||
PCDH17 | 3,3 | protocadherin 17 | ||
GJA5 | 3,2 | gap junction protein, alpha 5, 40kDa | ||
VIPR1 | 2,7 | vasoactive intestinal peptide receptor 1 | ||
GDF3 | 2,5 | growth differentiation factor 3 (GDF3), mRNA. | ||
SELL | 2,5 | selectin L (lymphocyte adhesion molecule 1) | ||
LRRC17 | 2,4 | leucine rich repeat containing 17 | ||
unknown | 2,4 | cDNA: FLJ21027 fis, clone CAE07110 | ||
HIST1H2BD | 2,4 | histone cluster 1, H2bd | ||
IL33 | 2,3 | interleukin 33 | ||
IL1RAPL1 | 2,2 | interleukin 1 receptor accessory protein-like 1 | ||
E2F2 | −2,5 | E2F transcription factor 2 (E2F2) | ||
DNMT1 | −2,9 | DNA (cytosine-5-)-methyltransferase 1 | ||
DLL4-ICD regulated | ||||
PCDH17 | 2,2 | protocadherin 17 | ||
JAG1-ICD regulated | ||||
PCDH17 | 2,2 | protocadherin 17 | ||
GJA5 | 2,2 | gap junction protein, alpha 5, 40kDa | ||
PPFIBP2 | 2,1 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | ||
VIPR1 | 2,1 | vasoactive intestinal peptide receptor 1 | ||
C18orf34 | 1,7 | chromosome 18 open reading frame 34 | ||
STS-1 | −2,2 | Cbl-interacting protein Sts-1 | ||
CENTG3 | −2,3 | centaurin, gamma 3 |
Table 1 . mRNA transcripts significantly changed 36 h after adenoviral infection of HUVEC with DLL1-ICD, DLL4-ICD or JAG1-ICD. Adenoviral GFP expression served as control.