Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Alcohol. 2012 Jun 12;46(6):585–593. doi: 10.1016/j.alcohol.2012.05.004

Figure 2.

Figure 2

Ethanol-induced second-order conditioning in infant rats derived from pregnant rats that were given 2.0 g/kg ethanol or vehicle (water) intragastrically (PE and PV groups, respectively) on gestational days 17 to 20 or were untreated (UT group), with the percent time spent on the rough CS2 texture (sandpaper) during the test as the dependent variable. During conditioning on PD14, the animals were given ethanol (0.5, 2.0, or 0.0 g/kg, i.g.) and stimulated 5–20 min post-administration with intraoral pulses of water (CS1; paired group) or experienced both stimuli separated by 120 min (unpaired groups). The next day, the animals experienced CS1–CS2 pairings and were then tested for CS2 preference. The figure depicts the percent time spent on sandpaper as a function of prenatal treatment, treatment during conditioning (i.e., paired or unpaired) and ethanol dose given at conditioning. To facilitate data visualization, the data were collapsed across sex. The latter factor did not affect tactile preference scores or significantly interact with the remaining factors. Asterisks (*) indicate significant differences between a paired group and its corresponding unpaired control (p < 0.05). Vertical bars indicate the SEM.