Table 1.
Baseline demographic characteristics and performance on individual tests
| Healthy control (n=229) | Mild cognitive impairment (n=397) | P-value for group differences | |
|---|---|---|---|
| Age [M (SD)] | 76.0 (5.0) | 74.9 (7.5) | 0.04 |
| Years of education [M (SD)] | 16.0 (2.9) | 15.7 (3.0) | 0.15 |
| Sex, Male [n (%)] | 119 (52.0) | 256 (64.5) | <0.01 |
| Race, White [n (%)] | 210 (91.7) | 371 (93.5) | 0.30 |
| Mini-Mental State Exam [M (SD)] | 29.1 (1.0) | 27.0 (1.8) | <0.001 |
| Memory | |||
| AVLT Learning (Trial 5 - Trial 1) [M (SD)] | 5.9 (2.3) | 3.3 (2.4) | <0.001 |
| AVLT Short Delay [M (SD)] | 8.1 (3.4) | 3.8 (3.1) | <0.001 |
| AVLT Long 30 min. Delay [M (SD)] | 7.4 (3.7) | 2.8 (3.3) | <0.001 |
| AVLT Recognition [M (SD)] | 12.9 (2.5) | 9.7 (3.7) | <0.001 |
| ADAS-Cog Delayed Recall [M (SD)] | 2.9 (1.7) | 6.2 (2.3) | <0.001 |
| ADAS-Cog Recognition [M (SD)] | 2.6 (2.3) | 4.6 (2.7) | <0.001 |
| Visuospatial ability | |||
| Clock Score [M (SD)] | 4.9 (0.4) | 4.6 (0.7) | <0.001 |
| Clock Copy Score [M (SD)] | 4.7 (0.7) | 4.2 (1.0) | <0.001 |
| ADAS-Cog Constructional Praxis [M (SD)] | 0.4 (0.5) | 0.6 (0.6) | <0.001 |
| Language | |||
| Verbal Fluency - animals (1 min) [M (SD)] | 19.9 (5.6) | 15.9 (4.9) | <0.001 |
| Verbal Fluency – vegetables (1 min) [M (SD)] | 14.7 (3.9) | 10.7 (3.5) | <0.001 |
| Boston Naming Test, spontaneous recall [M (SD)] | 27.3 (2.8) | 25.1 (3.7) | <0.001 |
| ADAS-Cog Naming, any incorrect [n (%)] | 15 (6.6) | 98 (24.7) | <0.001 |
| Executive function/processing speed | |||
| Trails B - Trails A (time) [M (SD)] | 50.1 (31.6) | 73.7 (47.6) | <0.001 |
| Trails A (time) [M (SD)] | 36.4 (13.2) | 0.0 (0.9) | <0.001 |
| Number Cancellation [M (SD)] | 24.7 (5.1) | 43.0 (18.1) | <0.001 |
| Digit Symbol [M (SD)] | 45.3 (9.6) | 36.7 (11.1) | <0.001 |
| Attention | |||
| Digit Span Forward [M (SD)] | 8.8 (2.0) | 8.2 (2.0) | 0.001 |
| Digit Span Backward [M (SD)] | 7.2 (2.0) | 6.2 (1.9) | <0.001 |
M mean, SD standard deviation.