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. 2012 Sep 28;303(11):H1319–H1331. doi: 10.1152/ajpheart.00160.2012

Fig. 4.

Fig. 4.

Inhibition of protein kinase B (AKT) inhibits Shh-induced LC3-II conversion. A: expression of p-AKT and AKT in Shh cells in the presence or absence of Shh induction (Dox) for different times (3, 5, 8, 12, and 24 h). B: effect of AKT inhibitor IV (AKTI IV, 10 μM) on the level of p-AKT and p-p70 S6K with or without Shh induction (Dox) for 8 h. *P < 0.01 vs. control and #P < 0.05 vs. Dox treated, n = 3. C: effect of AKTI IV on LC3-II conversion in cells with or without Shh induction (Dox). *P < 0.01 vs. control and #P < 0.05 vs. Dox treated, n = 3. D: effect of AKTI IV on green fluorescent protein (GFP)-LC3-II conversion in cells with and without Shh treatment. *P < 0.01 vs. control and #P < 0.05 vs. Shh treated, n = 3.