Skip to main content
. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Dev Biol. 2012 Aug 29;373(2):431–441. doi: 10.1016/j.ydbio.2012.08.015

Figure 1. Evolutionary conservation between members of zebrafish and mammalian growth factor independence family of zinc finger transcription factors.

Figure 1

(A) Deduced amino acid alignment of zebrafish (Dr), human (Hs) and mouse (Mm) growth factor independence transcription factors. The conserved SNAG domain and zinc finger motifs are marked. Zinc finger domains are underlined and numbered. Conserved amino acid residues are highlighted in black. (B) The phylogenetic relationship of homologous zebrafish, mouse, and human Gfi factors was constructed based on the J. Hein method. The MegAlign application in DNASTAR software was used for multiple alignment and construction of the phylogenetic dendrogram. Zebrafish gfi1ab (NP_958495.1) and gfi1aa (NP_001018612.1) cluster most closely with human GFI1A (NP_005254.2) and mouse Gfi1a (NP_034408.1), while zebrafish gfi1b (HQ599192) clusters most closely with human GFI1B (NP_004179.3) and mouse Gfi1b (NP_032140.1). The corresponding GenBank accession numbers are given in parenthesis.