Table 7. Regions that show a significant difference between people with MCI and AD in the association of metabolism and memory/executive function.

MNI coordinates and labels of regions with a group difference between AD and MCI in the association between brain metabolism and memory/executive function and at an uncorrected pthreshold of p<0.01 and cs=10 voxels. The results were obtained from a permutation test with 1,000 iterations. The smallest recordable p-level is thus 0.001. “MCI>AD” indicates that the slope of the association was larger in the MCI group, while “MCI<AD” denotes the converse scenario.

MNI-X	MNI-Y	MNI-Z	p(unc)	Sign	Lobe	Structure/Gyrus	Brodmann Area
2	62	20	0	MCI>AD	Right Frontal Lobe	Medial Frontal Gyrus	Brodmann area 10
2	−52	−38	0		Right Cerebellum	Nodule	n/a
6	−62	−12	0		Right Cerebellum	Culmen	n/a
4	−76	32	0		Right Occipital Lobe	Cuneus	Brodmann area 7
54	12	34	0.01		Right Frontal Lobe	Middle Frontal Gyrus	Brodmann area 9
2	−54	−38	0	MCI<AD	Right Cerebellum	Nodule	n/a
4	50	42	0		Right Frontal Lobe	Medial Frontal Gyrus	Brodmann area 9
4	42	48	0		Right Frontal Lobe	Medial Frontal Gyrus	Brodmann area 8
−50	4	−8	0		Left Temporal Lobe	Superior Temporal Gyrus	Brodmann area 22
6	−62	−10	0		Right Cerebellum	Culmen	n/a
2	40	30	0.01		Right Frontal Lobe	Medial Frontal Gyrus	Brodmann area 9
	MEM
−2	−52	−42	0	MCI>AD	Left Cerebellum	Cerebellar Tonsil	n/a
−60	0	−20	0		Left Temporal Lobe	Middle Temporal Gyrus	Brodmann area 21
−42	54	−10	0		Left Frontal Lobe	Middle Frontal Gyrus	Brodmann area 11
−56	4	−30	0		Left Temporal Lobe	Middle Temporal Gyrus	Brodmann area 21
−50	12	−34	0		Left Temporal Lobe	Middle Temporal Gyrus	Brodmann area 21
6	−8	12	0		Right Sub-lobar	Thalamus	n/a
14	−14	14	0		Right Sub-lobar	Thalamus	n/a
−12	12	−22	0		Left Frontal Lobe	Medial Frontal Gyrus	Brodmann area 25
−44	−14	−30	0.01		Left Temporal Lobe	Fusiform Gyrus	Brodmann area 20
−10	−84	38	0.01	MCI<AD	Parietal Lobe	Precuneus	Brodmann area 19
−42	−8	−34	0		Left Temporal Lobe	Inferior Temporal Gyrus	Brodmann area 20
−2	−54	−38	0		Left Cerebellum	Nodule	n/a
32	30	0	0		Right Frontal Lobe	Inferior Frontal Gyrus	Brodmann area 47
−46	16	−34	0		Left Temporal Lobe	Superior Temporal Gyrus	Brodmann area 38
−56	4	−32	0		Left Temporal Lobe	Middle Temporal Gyrus	Brodmann area 21
−46	2	−24	0		Left Temporal Lobe	Middle Temporal Gyrus	Brodmann area 21
−40	−10	18	0		Left Sub-lobar	Insula	Brodmann area 13
0	28	−16	0		Midline Frontal Lobe	Medial Frontal Gyrus	Brodmann area 25
6	−52	−46	0		Right Cerebellum	Cerebellar Tonsil	n/a
44	10	−26	0		Right Temporal Lobe	Superior Temporal Gyrus	Brodmann area 38
−2	−74	10	0		Left Occipital Lobe	Cuneus	Brodmann area 18
36	50	−16	0		Right Frontal Lobe	Superior Frontal Gyrus	Brodmann area 11
−46	12	−22	0		Right Temporal Lobe	Superior Temporal Gyrus	Brodmann area 38
−36	30	2	0		Left Frontal Lobe	Inferior Frontal Gyrus	Brodmann area 47
−8	16	−22	0		Left Frontal Lobe	Rectal Gyrus	Brodmann area 11
−30	0	−30	0.01		Left Limbic Lobe	Uncus	Amygdala
36	4	14	0.01		Right Sub-lobar	Insula	Brodmann area 13
−38	8	−30	0.01		Left Temporal Lobe	Superior Temporal Gyrus	Brodmann area 38